dictyNews Electronic Edition Volume 43, number 4 March 1, 2017 Please submit abstracts of your papers as soon as they have been accepted for publication by sending them to dicty@northwestern.edu or by using the form at http://dictybase.org/db/cgi-bin/dictyBase/abstract_submit. Back issues of dictyNews, the Dicty Reference database and other useful information is available at dictyBase - http://dictybase.org. Follow dictyBase on twitter: http://twitter.com/dictybase ========= Abstracts ========= Functional interaction of PkcA and PldB regulate aggregation and development in Dictyostelium discoideum Sean Singh, Wasima Mohamed, Annelie Aguessy, Ella Dyetta, Shriraj Shah, Mohammedasad Khan, Ramamurthy Baskar, Derrick Brazill,* Cellular Signalling, in press Multicellular development in Dictyostelium discoideum involves tightly regulated signaling events controlling the entry into development, initiation of aggregation and chemotaxis, and cellular differentiation. Here we show that PkcA, a Dictyostelium discoideum Protein Kinase C-orthologue, is involved in quorum sensing and the initiation of development, as well as cAMP sensing during chemotaxis. Additionally, by epistasis analysis we provide evidence that PkcA and PldB (a Phospholipase D-orthologue) functionally interact to regulate aggregation, differentiation, and cell-cell adhesion during development. Finally, we show that PkcA acts as a positive regulator of intracellular PLD-activity during development. Taken together, our results suggest that PkcA act through PldB, by regulating PLD-activity, in order to control events during development. submitted by: Derrick Brazill [brazill@genectr.hunter.cuny.edu] ============================================================== [End dictyNews, volume 43, number 4]