| Page Contents: Abstract |
Yan, Jianshe, Mihaylov, Vassil, Xu, Xuehua, Brzostowski, JA Joseph A, Li, Hongyan, Liu, Lunhua, Veenstra, TD Timothy D, Parent, CA Carole A, Jin, Tian, (2012)
' A G?? Effector, ElmoE, Transduces GPCR Signaling to the Actin Network during Chemotaxis. '
Dev. Cell
22
92-103
|
| Abstract:Activation of G protein-coupled receptors (GPCRs) leads to the dissociation of heterotrimeric G-proteins into G? and G?? subunits, which go on to regulate various effectors involved in a panoply of cellular responses. During chemotaxis, G?? subunits regulate actin assembly and migration, but the protein(s) linking G?? to the actin cytoskeleton remains unknown. Here, we identified a G?? effector, ElmoE in Dictyostelium, and demonstrated that it is required for GPCR-mediated chemotaxis. Remarkably, ElmoE associates with G?? and Dock-like proteins to activate the small GTPase Rac, in a GPCR-dependent manner, and also associates with Arp2/3 complex and F-actin. Thus, ElmoE serves as a link between chemoattractant GPCRs, G-proteins and the actin cytoskeleton. The pathway, consisting of GPCR, G??, Elmo/Dock, Rac, and Arp2/3, spatially guides the growth of dendritic actin networks in pseudopods of eukaryotic cells during chemotaxis. | |||||||
| Status: | ppublish | Type: | Journal article | Source: | PUBMED | PubMed ID: | 22264729 |
| Home| Contact dictyBase| Site Map |
Supported by NIH (NIGMS and NHGRI)
|
