Page Contents: Abstract | Summary Chart

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Rai, A., Nothe, H., Tzvetkov, N., Korenbaum, E., Manstein, J., (2010) ' Dictyostelium dynamin B modulates cytoskeletal structures and membranous organelles. ' Cell Mol Life Sci

 

Abstract:Dictyostelium discoideum cells produce five dynamin family proteins. Here, we show that dynamin B is the only member of this group of proteins that is initially produced as a preprotein and requires processing by mitochondrial proteases for formation of the mature protein. Our results show that dynamin B-depletion affects many aspects of cell motility, cell-cell and cell-surface adhesion, resistance to osmotic shock, and fatty acid metabolism. The mature form of dynamin B mediates a wide range and unique combination of functions. Dynamin B affects events at the plasma membrane, peroxisomes, the contractile vacuole system, components of the actin-based cytoskeleton, and cell adhesion sites. The modulating effect of dynamin B on the activity of the contractile vacuole system is unique for the Dictyostelium system. Other functions displayed by dynamin B are commonly associated with either classical dynamins or dynamin-related proteins.
Status:	e-pub ahead of print	Type:	Journal article	Source:	PUBMED	PubMed ID:	21086149

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	Genes addressed in this paper
	dymB
Topics in this paper
Mammalian Gene Related	X
Cytoskeleton	X
Non-mammalian Gene Related	X
Cellular Location	X
Function/Process	X
Endocytosis	X
Antibodies	X
Adhesion	X
Protein Physical Properties	X
Protein Functional Domain	X
Strains/Constructs	X
Post-Translational Modifications	X
Chemotaxis/Motility	X
DNA/RNA Sequence Features	X
Mutants/Phenotypes	X
Growth	X