Dictyostelium Mutants

Phenotypes for Dictyostelium mutants

View other mutant types: All mutant strains - Null - Overexpression - Multiple - Other - Developmental

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Systematic Name Strain Descriptor Associated gene(s) Phenotypes
DBS02354121C7gp130decreased cell-substrate adhesion | delayed development | increased growth rate
DBS023541324EH6racEabolished cytokinesis
DBS02354142F5gp130decreased cell-substrate adhesion | delayed development | increased growth rate
DBS02386015NT-5NTmultiple tips in culminant | delayed tip formation | multiple tips in mound
DBS0235584CF45-1-cf45-1increased aggregate size | decreased cell motility | increased cell-cell adhesion | decreased aggregate size | increased intracellular glucose level
DBS0235585CF50-cf50-1increased aggregate size | increased gene expression | increased cell-cell adhesion | decreased extracellular counting factor component(s) level | increased protein level
DBS0235612CMFR1-cmfBdecreased gene expression | abolished aggregation
DBS0235596ChLim-ChLimincreased growth rate | increased phagocytosis
DBS0252637DAip1-aip1decreased pinocytosis | delayed cytokinesis | decreased growth rate | decreased phagocytosis
DBS0235659DD3-3-DD3-3decreased gene expression | precocious aggregation
DBS0236049DDB_G0268012-DDB_G0268012wild type
DBS0236046DDB_G0268158-DDB_G0268158wild type
DBS0236039DDB_G0268678-DDB_G0268678wild type
DG1007DDB_G0269232-DDB_G0269232abolished culmination
DBS0236025DDB_G0270366-DDB_G0270366wild type
DBS0236026DDB_G0270368-DDB_G0270368wild type
DBS0236036DDB_G0270744-DDB_G0270744wild type
DBS0236043DDB_G0276221-DDB_G0276221wild type
DBS0236042DDB_G0276689-DDB_G0276689wild type
DBS0236041DDB_G0277179-DDB_G0277179wild type
DBS0236045DDB_G0277575-DDB_G0277575wild type
DBS0236044DDB_G0278315-DDB_G0278315wild type
DBS0236038DDB_G0279005-DDB_G0279005wild type
DBS0236032DDB_G0279163-DDB_G0279163wild type
DBS0236033DDB_G0279163-DDB_G0279163wild type
DBS0236028DDB_G0279609-DDB_G0279609wild type
DBS0236029DDB_G0279609-DDB_G0279609wild type
DBS0236035DDB_G0280481-DDB_G0280481wild type
DBS0236019DDB_G0281735-DDB_G0281735wild type
DBS0236020DDB_G0281735-DDB_G0281735wild type
DBS0236027DDB_G0290225-DDB_G0290225wild type
DG1003DDB_G0291992-DDB_G0291992aberrant culminant morphology
DBS0236037DDB_G0292186-DDB_G0292186wild type
DBS0236023DDB_G0293116-DDB_G0293116wild type
DBS0236024DDB_G0293116-DDB_G0293116wild type
DBS0236030DDB_G0293762-DDB_G0293762wild type
DG1039DG1039-DDB_G0284037aberrant fruiting body morphology
DG1040DG1040-DDB_G0276029aberrant fruiting body morphology
DG1041DG1041-DDB_G0269126aberrant fruiting body morphology
DG1054DG1054-DDB_G0277719aberrant fruiting body morphology
DG1060DG1060-DDB_G0281953aberrant fruiting body morphology
DG1062DG1062-DDB_G0286351aberrant fruiting body morphology
DG1074DG1074-DDB_G0272108aberrant fruiting body morphology
DG1080DG1080-DDB_G0281559aberrant fruiting body morphology
DG1091DG1091-DG1091decreased fruiting body size
DG1098DG1098-DG1098decreased fruiting body size
DG1104DG1104-DDB_G0283535abolished aggregation
DG1105DG1105-DG1105abolished aggregation
DG1106DG1106-DG1106abolished aggregation
DG1110DG1110-DDB_G0269128aberrant fruiting body morphology
DG1112DG1112-DG1112decreased stalk width
DG1113DG1113-DG1113increased stalk length
DG1122DG1122-DG1122aberrant fruiting body morphology
DG1124DG1124-DG1124development arrests at loose aggregate stage
DG2033DG2033-DG2033development arrests at mound stage
DG2044DG2044-DG2044development arrests at loose aggregate stage
DBS0266700Dd5P1-Dd5P1wild type
DBS0235660Dd5P2-Dd5P2wild type | increased basal F-actin level
DBS0266702Dd5P3-Dd5P3wild type
DBS0266692Dd5P4-Dd5P4decreased growth rate | decreased phagocytosis | decreased engulfment during phagocytosis | multiple tips in mound
DBS0266693Dd5P4-/ [act15]: Dd5P4Dd5P4wild type
DBS0266719Dd5P4-/ [act15]: Dd5P4: GFPDd5P4wild type
DBS0266695Dd5P4-/ [act15]: GAP5P4Dd5P4decreased growth rate | multiple tips in mound
DBS0266720Dd5P4-/ [act15]: Hs-OCRLDd5P4decreased phagocytosis
DBS0266721Dd5P4-/ [act15]: Hs-OCRL(D422A)Dd5P4decreased phagocytosis
DBS0266694Dd5P4-/ [act15]: cat5P4Dd5P4decreased growth rate | multiple tips in mound
DBS0235940EB1-eb1aberrant mitosis
DBS0236015GEG04K11 (tmcB- in KAX3)tmcBsmall macrocysts | increased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0236016GEG04V12 (tmcB- in V12)tmcBsmall macrocysts | increased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0236017GEG10K23 (tmcC- in KAX3)tmcCincreased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0236018GEG10V03 (tmcC- in V12)tmcCincreased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0302603GFP: disgorgin/ disgorgin-DDB_G0280955wild type
DBS0302615GFP: phgA(1-274: 283-438)/ phgA-phgAaberrant response to hypo-osmotic stress
DBS0302614GFP: phgA/ phgA-phgAwild type
DBS0236085GP138C-cfrCwild type
HTY506HTY506pkaRaberrant spore morphology | decreased spore viability | decreased phosphorylation of actin | increased sporulation | precocious development | aberrant fruiting body morphology
DBS0236716PAKc-pakCdecreased chemotaxis rate | decreased lateral pseudopod suppression
DBS0236779PIPkinA-pik6decreased gene expression | abolished aggregation
DBS0236783PKAcat-pkaCabolished aggregation
DBS0236840R7nosAdevelopment arrests at mound stage
DBS0236900RIP3ripAdecreased cell polarity | abolished activation of adenylate cyclase | decreased chemotaxis rate | abolished aggregation | decreased myosin II assembly
DBS0236996TL26cotBaberrant spore coat morphology
DBS0304456[AS]alrA/ gcsA-alrA | gcsAdecreased growth rate in suspension | cell cycle arrest
DBS0236827[AS]proA/ proB-proA | proBincreased basal F-actin level | abolished growth | development arrests at slug stage | aberrant cytokinesis | decreased cell motility
DBS0238036[AS]proA/ proB-/ [act15]: proAproA | proBwild type
DBS0238037[AS]proA/ proB-/ [act15]: proBproA | proBwild type
DBS0302602[OE]: disgorgin(Delta-Fbox)/ disgorgin-DDB_G0280955wild type
DBS0302601[OE]: disgorgin(Q551A)/ disgorgin-DDB_G0280955aberrant contractile vacuole organization and biogenesis
DBS0302600[OE]: disgorgin(R515A)/ disgorgin-DDB_G0280955aberrant contractile vacuole organization and biogenesis
DBS0302599[OE]: disgorgin/ disgorgin-DDB_G0280955wild type
DBS0302610[OE]: disgorgin/ phgA-DDB_G0280955 | phgAaberrant contractile vacuole organization and biogenesis
DBS0302611[OE]: phgA/ disgorgin-DDB_G0280955 | phgAaberrant contractile vacuole organization and biogenesis
DBS0302656[act15]: cnrN/ cnrN-cnrNwild type
DBS0302658[act15]: cnrN/ smlA-cnrN | smlAdecreased fruiting body size
DBS0304457[act15]: sodA/ gcsA-gcsA | sodAwild type
DBS0304460[act]: alrA/ gcsA-alrA | gcsAwild type
HAD186aarA-aarAaberrant tip formation | aberrant establishment and/ or maintenance of cell polarity | aberrant stalk formation | aberrant Golgi localization | aberrant centrosome localization | decreased sporulation | aberrant fruiting body morphology
DBS0266687abiA-abiAdecreased protein level | aberrant cytokinesis | decreased growth rate | decreased chemotaxis to folate | aberrant protein localization
DBS0266688abiA-abiAaberrant protein localization
DBS0305672abpB-abpBincreased filopodium formation
DBS0236077abpC-abpCaberrant thermotaxis | aberrant phototaxis
DBS0237938abpC-/ [act15]: GFP: abpC(9-148)abpCaberrant phototaxis
DBS0235426abpC-/ [act15]: abpCabpCwild type
DBS0237945abpC-/ [act15]: abpC(1-348: 449-857): GFPabpCaberrant F-actin organization | aberrant phototaxis
DBS0237946abpC-/ [act15]: abpC(1-556: 644-857): GFPabpCaberrant F-actin organization | aberrant phototaxis
DBS0237941abpC-/ [act15]: abpC(1-739): GFPabpCaberrant phototaxis
DBS0237949abpC-/ [cotB]: abpC: GFPabpCaberrant phototaxis
DBS0237948abpC-/ [ecmA]: abpC: GFPabpCwild type
DBS0235427abpD-abpDdecreased cell-cell adhesion | decreased spore viability | delayed development | aberrant development
DBS0235428abpE-abpE-1 | abpE-2increased lateral pseudopod formation
DBS0349851abpE-abpE-1 | abpE-2increased phagocytosis
DBS0349852abpE-/ [act15]: abpEabpE-1 | abpE-2decreased phagocytosis
DBS0235562acaA-acaAabolished aggregation | decreased adenylate cyclase activity | abolished cell polarity | abolished streaming
GP6acaA-acaAaberrant F-actin organization | increased lateral pseudopod formation | decreased chemotaxis rate | aberrant cell morphology
DBS0306125acapA-acapAwild type
DBS0306127acapB-acapBwild type
TL177acbA-acbAincreased sensitivity to cisplatin | abolished SDF production | decreased spore viability | abolished sorting to prestalk region
DBS0235440acgA-acgAprecocious spore germination
DBS0237788acgA-acgAdecreased gene expression | decreased prespore cell differentiation
DBS0237790acgA-/ [acrA]: lacZacgA | acrAmislocalized gene expression
DG1100acrA-acrAdecreased gene expression | increased stalk length | spores inviable | decreased sporulation
DBS0237786acrA-/ [act15]: acgA(1-401)acgA | acrAdecreased gene expression | decreased prespore cell differentiation | decreased sporulation
DBS0238203adrm1-adrm1-1aberrant response to nutrients | precocious gene expression | precocious development
DBS0235457ahhA-ahhAaberrant culminant morphology
DBS0266759alp-alpwild type
DBS0235513alrA-alrAincreased aggregate size | decreased intracellular glucose level | decreased cell motility | decreased extracellular counting factor component(s) level
DBS0235473alrA-/ [act15]: alrAalrAwild type
DBS0235474alxA-alxAdevelopment arrests at loose aggregate stage | decreased growth rate | aberrant fruiting body morphology
DBS0235475alxA-alxAabolished sporulation | decreased gene expression | development arrests at mound stage | aberrant fruiting body morphology
DBS0235488alxA-/ [act15]: FLAG: alxAalxAdelayed development
DBS0235476alxA-/ [act15]: alxA(1-596): myc2alxAwild type
DBS0235477alxA-/ [act15]: alxA(1-697): myc2alxAwild type
DBS0235478alxA-/ [act15]: alxA(155-697): myc2alxAaberrant fruiting body morphology
DBS0235479alxA-/ [act15]: alxA(293-697): myc2alxAaberrant fruiting body morphology
DBS0235480alxA-/ [act15]: alxA(460-794): myc2alxAaberrant fruiting body morphology
DBS0235481alxA-/ [act15]: alxA(D310A/ N311A)alxAwild type
DBS0235482alxA-/ [act15]: alxA(Q181E/ Q183)alxAwild type
DBS0235483alxA-/ [act15]: alxA(S700A/ S704A/ S708A)alxAwild type
DBS0235484alxA-/ [act15]: alxA(S700D/ S704D/ S708D)alxAwild type
DBS0235485alxA-/ [act15]: alxA(Y315D)alxAwild type
DBS0235486alxA-/ [act15]: alxA(Y315F)alxAwild type
DBS0235487alxA-/ [act15]: alxA: myc2alxAwild type
DBS0235489alyA-alyAincreased phagocytosis
DG1114amdA-amdAdecreased spore viability | translucent sorus | increased prestalk A cell differentiation
HM1158amdA-amdAdecreased fruiting body size | decreased sporulation | increased aspidocyte differentiation
DBS0235490amiB-amiBabolished aggregation
DBS0235491amiB-amiBdecreased cAMP-induced cGMP pulse | abolished down-regulation of growth phase genes | decreased gene expression | abolished aggregation | decreased chemotaxis to cAMP | decreased cAMP-induced cAMP pulse
DBS0235493ampA-ampAdelayed tip formation | increased cell-cell adhesion | increased cell-substrate adhesion | mislocalized gene expression | delayed development | precocious gene expression | decreased prestalk cell differentiation | delayed gene expression
BS155amtA-amtAdecreased slug migration | decreased aggregate size | decreased fruiting body size | increased growth rate
DBS0267100amtA-amtAdecreased spore viability | decreased aggregate size | increased number of aggregates | decreased extracellular ammonia level | increased intracellular glucose level | decreased stalk length | increased intracellular ammonia level
DBS0267101amtA-/ [OE]: amtAamtAwild type
BS154amtC-amtCdecreased gene expression | development arrests at slug stage | mislocalized gene expression | delayed culmination | aberrant protein localization | aberrant fruiting body morphology
DBS0235501amtC-/ [act15]: cudAamtC | cudAdelayed culmination
DBS0235502amtC-/ [ecmA]: cudAamtC | cudAdelayed culmination
DBS0235503amtC-/ [pspA]: cudAamtC | cudAdevelopment arrests at slug stage
DBS0235505apm1-apm1aberrant contractile vacuole organization and biogenesis | decreased spore germination | aberrant response to hypo-osmotic stress | decreased growth rate | aberrant endosome morphology | delayed development | decreased stalk width
DBS0305085apm2-/ [dscB]: GFP: vamp7Aapm2 | vamp7Aincreased localization of protein to the plasma membrane
DBS0235507apm3-apm3decreased pinocytosis | increased exocytosis | aberrant post-lysosome organization and biogenesis | aberrant endosome morphology
DBS0305083apm3-/ [dscB]: GFP: vamp7Aapm3 | vamp7Aincreased localization of protein to the plasma membrane
DBS0235508apm4-apm4wild type
DBS0235509aprA-aprAincreased aggregate size | decreased spore viability | aberrant cytokinesis | increased growth rate | aberrant fruiting body morphology | decreased sporulation
DBS0235510aprA-/ actin15: : aprAaprAdecreased growth rate | aberrant fruiting body morphology
DBS0238124aqpA-aqpAdecreased spore viability
DBS0235511arkA-arkAincreased gene expression | aberrant fruiting body morphology
DBS0235514aslA-aslA-1 | aslA-2wild type
DBS0236305atg1-atg1aberrant macroautophagy | abolished autophagic vacuole formation
DBS0236304atg1-atg1aberrant macroautophagy | abolished autophagic vacuole formation
HR131atg1-atg1abolished sporulation | decreased growth rate in suspension | abolished macroautophagy | increased number of autophagosomes | aberrant cellular response to nitrogen starvation | abolished stalk cell differentiation | abolished aggregation | decreased growth rate on bacterial plates
DBS0238085atg1-/ [act15]: atg1atg1wild type
DBS0238092atg1-/ [act15]: atg1(1-628)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238087atg1-/ [act15]: atg1(K36A)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238093atg1-/ [act15]: atg1(P138S)atg1abolished aggregation
HR75atg5-atg5aberrant macroautophagy | abolished sporulation | aberrant cellular response to nitrogen starvation | multiple tips | abolished aggregation
HR174 atg6-atg6Aaberrant macroautophagy | aberrant cellular response to nitrogen starvation | multiple tips | decreased fruiting body size | decreased stalk length | decreased sporulation
HR79atg7-atg7aberrant macroautophagy | abolished sporulation | aberrant cellular response to nitrogen starvation | multiple tips
HR141atg8-atg8aberrant macroautophagy | aberrant spore morphology | increased sensitivity to cisplatin | aberrant cellular response to nitrogen starvation | multiple tips | decreased fruiting body size | decreased sporulation
DBS0305977atg9-atg9increased stalk width | aberrant sorus morphology | decreased phagocytosis | decreased growth rate | aberrant slug migration | aberrant fruiting body morphology | aberrant slug formation | multiple tips in mound
TL97cadA-cadAmultiple tips | decreased sporulation | delayed culmination | increased prestalk cell differentiation
DBS0235568car4-carDincreased gene expression | decreased gene expression | aberrant fruiting body morphology
DBS0235570carB-carBdevelopment arrests at mound stage
DBS0235573carmil-carmildecreased pinocytosis | decreased growth rate | decreased basal F-actin level | decreased aggregate size
IR40catA-catAabolished catalase activity
IR41catA-catAabolished catalase activity
IR29catA-catAincreased sensitivity to H2O2 (peroxide)
DBS0235574catB-catBspores hypersensitive to H2O2 (peroxide) | delayed development
DBS0304455cblA-cblA-1 | cblA-2abolished basal disc formation | aberrant slug formation | aberrant signal transduction
DBS0235575cbpJ-cbpJwild type
DBS0235661cdk8-cdk8decreased gene expression | mislocalized gene expression | abolished aggregation
DBS0235578cdk8-/ [cdk8]: cdk8cdk8wild type
DBS0306226cenB-cenBabolished localization of protein to the microtubule organizing center | increased number of centrosomes | aberrant cell separation during cytokinesis | aberrant nuclear envelope morphology | aberrant nucleus morphology | aberrant cytokinesis | decreased microtubule nucleation | aberrant centrosome organization
DBS0306227cenB-/ [act15]: RFP: cenBcenBwild type
DBS0302444cfaD-cfaDincreased growth rate | aberrant fruiting body morphology
DBS0302446cfaD-/ [act15]: cfaDcfaDwild type
HO101chcA-chcAdecreased pinocytosis | aberrant cytokinesis | decreased growth rate
HO103chcA-chcAabolished sporulation | abolished cytokinesis | abolished gene expression | delayed aggregation | abolished growth in suspension | aberrant fruiting body morphology
DBS0235588chcA-/ [act15]: GFP: mhcAchcA | mhcAdecreased positive regulation of GTPase activity
DBS0302455chcA-/ [act15]: epnA: GFPchcA | epnAaberrant localization of a protein to coated pits
DBS0235589chcA-/ [cotB]: lacZchcAmislocalized gene expression
DBS0235590chcA-/ [ecmA]: lacZchcAmislocalized gene expression
DBS0235591chcA-/ [ecmB]: lacZchcAmislocalized gene expression
DBS0235592chcA-/ [pspA]: lacZchcAmislocalized gene expression
DBS0235601clc-clcabolished cytokinesis | aberrant response to hypo-osmotic stress | abolished growth | aberrant fruiting body morphology
DBS0235604clc-/ [act15]: GFP-clc(146-194)clcabolished cytokinesis | wild type | aberrant fruiting body morphology
DBS0235605clc-/ [act15]: GFP-clc(85-124)clcabolished cytokinesis | wild type | aberrant fruiting body morphology
DBS0235607clc-/ [act15]GFP: clc(1-124)clcabolished cytokinesis | wild type | aberrant fruiting body morphology
DBS0235608clmA-clmAaberrant response to hypo-osmotic stress
DBS0235613cnrB-cnrBwild type
DBS0302655cnrN-cnrNaberrant streaming | increased cAMP-induced cAMP pulse | increased F-actin polymerization | increased number of aggregates
HG1770cnxA-cnxAdecreased extracellular Ca2+ uptake | increased cytosolic Ca2+ response
DBS0235615cofB-cofBwild type
DBS0235616cofC-cofC-1wild type
DBS0235617comB-comBabolished culmination
DG1016comB-comBabolished culmination
DBS0235618comC-comCaberrant streaming | aberrant aggregation
DBS0235619comD-comDabolished culmination
DBS0235620comE-comEtranslucent sorus | aberrant fruiting body morphology
DBS0235621comF-comF-1 | comF-2abolished aggregation
DBS0235622comG-comGdevelopment arrests at mound stage | multiple tips
DBS0235623comH-comHdevelopment arrests at mound stage
HG1570corA-corAaberrant cytokinesis | decreased growth rate | decreased cell motility | aberrant cell morphology
HG1571corA-corAaberrant cytokinesis | decreased growth rate | decreased cell motility | aberrant cell morphology
HG1569corA-corAaberrant cytokinesis | decreased growth rate | decreased cell motility | aberrant cell morphology
DBS0305825corB-corBaberrant phagocytosis | decreased growth rate | increased lateral pseudopod formation | increased cell-substrate adhesion
TL55cotA-cotAaberrant spore coat morphology
TL52cotC-cotCaberrant spore coat morphology
DBS0238297cpnA-cpnAdelayed response to hypo-osmotic stress | decreased culmination | decreased growth rate | aberrant cytokinesis | delayed development | aberrant fruiting body morphology
DBS0238320cpnA-/ [act15]: GFP: cpnAcpnAdelayed response to hypo-osmotic stress | decreased culmination | delayed development
DBS0235627crlA-crlAincreased aggregate size | delayed tip formation | decreased sorting to prestalk region | increased growth rate
DBS0235628crlA-/ [crlA]: crlAcrlAincreased aggregate size
DBS0235629crlB-crlBwild type
DBS0235630crlC-crlCwild type
HG1768crtA-crtAdecreased extracellular Ca2+ uptake | increased cytosolic Ca2+ response
DBS0235633crtf-crtfabolished sporulation | decreased gene expression | abolished aggregation
WTC127cshA-cshAdevelopment arrests at loose aggregate stage | decreased phagocytosis | decreased growth rate | delayed aggregation
DBS0235624ctnA-ctnAdecreased protein level | increased cAMP-induced cGMP pulse | increased aggregate size | decreased basal F-actin level | increased cell-cell adhesion | increased GTP-gamma-S-stimulated guanylyl cyclase activity | increased protein level | increased cell motility | increased intracellular glucose level | decreased cAMP-induced cAMP pulse | decreased myosin II assembly
DBS0235636ctnB-ctnBdecreased gene expression | increased number of aggregates | decreased fruiting body size
DBS0304927ctnnA-ctnnAwild type
DG1071ctr9-ctr9aberrant fruiting body morphology
DG1058ctrA-ctrAdecreased fruiting body size
DBS0235598ctxA-ctxAaberrant cytokinesis | aberrant cell morphology
HS1151ctxA-ctxAaberrant cytokinesis | decreased growth rate
DBS0237568ctxA-/ [RNAi]enlActxA | enlAwild type
DBS0237536ctxA-/ [act15]: enlA(92-497)ctxA | enlAwild type
DBS0235600ctxB-ctxBaberrant cytokinesis | aberrant cell morphology
DBS0235639cudA-cudAabolished sporulation | decreased gene expression | development arrests at slug stage | abolished stalk cell differentiation
DBS0235640culA-culAmultiple tips | development arrests at tipped mound stage
DBS0235641culA-/ [cotC]: culAculAincreased sorus size | decreased stalk length | decreased sporulation
DBS0235642culA-/ [ecmA]: culAculAincreased sorus size | decreased stalk length
DBS0235643culA-/ [pkaC]pkaCculA | pkaCwild type
DBS0266745culB-culBdecreased fruiting body size | precocious gene expression | aberrant slug formation | decreased sporulation | multiple tips in mound
DBS0266761culB-/ [act15]: pkaCculB | pkaCabolished gene expression | abolished sporulation | precocious gene expression | abolished aggregation
DBS0235651cybA-cybAabolished sporulation | aberrant development
AK108dagA-dagAabolished gene expression | decreased gene expression | abolished activation of adenylate cyclase | abolished aggregation
DBS0235652dagA-/ [act15]: dagAdagAwild type
DBS0235653darA-darAdecreased cell polarity | decreased cell motility | decreased aggregate size | abolished aggregation
DBS0236307dcsA-dcsAabolished cellulose biosynthesis
DG1099dcsA-dcsAabolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | abolished stalk formation | abolished stalk cell differentiation
DG1128dcsA-dcsAabolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | abolished stalk formation
TL127dcsA-dcsAabolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | aberrant stalk formation | abolished stalk formation | abolished stalk cell differentiation
TL128dcsA-/ [act15]: dcsAdcsAwild type
DBS0349804detA-detAincreased aggregate size | decreased growth rate | delayed development
DBS0349813detA-/ [cotB]: GFPdetAdecreased prespore cell differentiation
DBS0349811detA-/ [ecm0]: lacZdetAaberrant prestalk O cell differentiation
DBS0349812detA-/ [ecmA0]: GFPdetAincreased prestalk cell differentiation
DBS0349808detA-/ [ecmA0]: lacZdetAincreased prestalk cell differentiation
DBS0349809detA-/ [ecmA]: lacZdetAincreased prestalk A cell differentiation
DBS0349810detA-/ [ecmB]: lacZdetAdelayed development
DBS0235695dgkA-dgkAdecreased spore viability | increased myosin II assembly | decreased chemotaxis rate | aberrant development
AK299dhkA-dhkAaberrant stalk morphogenesis | increased sporulation in the presence of 8-Br-cAMP | increased gene expression | mislocalized gene expression | decreased sporulation | aberrant fruiting body morphology
DBS0235704dhkB-dhkBprecocious spore germination
TL135dhkC-dhkCprecocious culmination | decreased spore germination | precocious aggregation | precocious development
DBS0235710dhkK-dhkKaberrant slug migration | delayed culmination | delayed gene expression
DBS0235712dhkK-/ [act15]: dhkK(D1125N)dhkKaberrant fruiting body morphology
DBS0348046dhkM-dhkMabolished autophagic vacuole formation | delayed development
DBS0348047dhkM-dhkMabolished autophagic vacuole formation | delayed development
DBS0235895dimA-dimAthin fingers | long fingers | abolished prestalk cell differentiation | increased slug size | increased prespore cell differentiation | decreased prestalk O cell differentiation | aberrant fruiting body morphology
DBS0235901dimB-dimBabolished response to DIF
DBS0235903dimB-/ [act15]: dimA: GFPdimA | dimBabolished localization of protein to the nucleus
DBS0235904dimB-/ [act15]: dimB: GFPdimBwild type
DBS0235902dimB-/ [cotB]: lacZdimBincreased prespore cell differentiation
DBS0235906dimB-/ [ecmAO]: lacZdimBdecreased prestalk O cell differentiation
DBS0235907dimB-/ [ecmO]: lacZdimBaberrant prestalk cell differentiation
DBS0302608disgorgin(1-571: 581-733)/ disgorgin-DDB_G0280955aberrant contractile vacuole organization and biogenesis | aberrant cellular localization
DBS0302597disgorgin-DDB_G0280955aberrant contractile vacuole organization and biogenesis | aberrant response to hypo-osmotic stress
DBS0302607disgorgin-/ [OE]: lvsADDB_G0280955 | lvsAaberrant contractile vacuole organization and biogenesis
DBS0302606disgorgin-/ [OE]: lvsDDDB_G0280955 | lvsDwild type
DBS0302678disgorgin-/ [OE]: rab8ADDB_G0280955 | rab8Aaberrant contractile vacuole organization and biogenesis
DBS0302604disgorgin-/ lvsA-DDB_G0280955 | lvsAwild type
DBS0302605disgorgin-/ lvsD-DDB_G0280955 | lvsDaberrant contractile vacuole organization and biogenesis
DBS0304919dlpA-dlpAaberrant cytokinesis
DBS0304920dlpB-dlpBaberrant cytokinesis
DBS0304921dlpC-dlpCaberrant cytokinesis
DBS0235913dmpA-dmpAaberrant streaming | translucent sorus | delayed development | decreased stalk cell differentiation | decreased sporulation | aberrant fruiting body morphology
HM1030dmtA-dmtAthin fingers | decreased outer basal disc size | abolished prestalk O cell differentation | abolished DIF production | delayed tip formation | decreased lower cup size | delayed development | decreased prestalk O cell differentiation | aberrant fruiting body morphology | decreased prestalk cell differentiation
DBS0235914dnapkcs-dnapkcsincreased sensitivity to DNA-damaging agents
DBS0266875dnapkcs-/ GFP: pcnadnapkcs | pcnaaberrant response to DNA damaging agents
DBS0235915dng1-dng1decreased growth rate | delayed aggregation
DBS0235917dnmA-dnmAdecreased cytosine methylation in genomic DNA
DBS0235916dnmA-dnmAaberrant culminant morphology | translucent sorus | decreased cytosine methylation in genomic DNA | decreased sporulation
DG2015docA-docAdevelopment arrests at mound stage
DBS0235920dokA-dokAaberrant response to hyperosmotic stress | translucent sorus | decreased sporulation
DBS0349789dotA-dotAdecreased growth rate | increased sensitivity to UV light | decreased spore size | delayed development | abolished histone H3-K79 methylation
HAD172dpoA-dpoAaberrant development
HAD200dpoA-dpoAaberrant development
HAD201dpoA-dpoAaberrant development
HAD202dpoA-dpoAaberrant development
HAD203dpoA-dpoAaberrant development
DBS0238474drkC-drkCdecreased phagocytosis | decreased phagolysosome formation
DBS0238511drkC-/ [act15]: drkC(1-497): YFPdrkCdecreased phagocytosis
DBS0238513drkC-/ [act15]: drkC(K518R): YFPdrkCdecreased phagocytosis
DBS0238475drkC-/ [act15]: drkC: YFPdrkCwild type
DBS0235924dscA-dscA-1 | dscA-2aberrant cell morphology
DBS0235925dstA-dstAabolished gene expression | increased gene expression | decreased gene expression | delayed aggregation | mislocalized gene expression | decreased cell motility | abolished stalk cell differentiation | abolished sorting to prestalk region | aberrant fruiting body morphology
DBS0235926dstA-dstAdelayed aggregation | mislocalized gene expression | decreased cell motility | abolished stalk cell differentiation | abolished sorting to prestalk region | aberrant fruiting body morphology
DBS0238237dstA-/ GFP: dstA(237-707): ORF+dstAabolished culmination | decreased stalk length
DBS0238236dstA-/ GFP: dstA(237-707): ORF+/ [OE]dutA(751-1322)dstA | dutAdecreased stalk length
DBS0252824dstA-/ GFP: dstA(237-707): ORF+/ [act15]: 2C2C | dstAaberrant fruiting body morphology
DBS0252823dstA-/ GFP: dstA(237-707): ORF+/ [act15]: 7E7E | dstA | hssBwild type
DBS0252826dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0276165DDB_G0276165 | dstAaberrant fruiting body morphology
DBS0252825dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0282325DDB_G0282325 | dstAaberrant fruiting body morphology
DBS0252816dstA-/ GFP: dstA(237-707): ORF+/ [act15]: hssAdstA | hssAwild type
DBS0235928dstA-/ [act15]: dstAdstAwild type
DBS0235929dstA-/ [cprB]: dstAdstAwild type
DBS0235930dstA-/ [ecmAO]: dstAdstAwild type
DBS0235931dstB-dstBdecreased gene expression | increased gene expression | decreased growth rate
DBS0235933dstB-/ [act15]: dstBdstBwild type
DBS0235934dstB-/ [act15]: dstB(L1025R)dstBwild type
DBS0235935dstB-/ [act15]: dstB(Y1143F)dstBwild type
DBS0235937dtfA-dtfAdelayed tip formation | aberrant cytokinesis | aberrant fruiting body morphology
DBS0238234dutA-dutAwild type
DBS0235939dwwA-dwwAaberrant cytokinesis | aberrant F-actin organization | aberrant cell morphology
DBS0347874dymA-dymAdecreased pinocytosis | aberrant cell separation during cytokinesis | decreased cell polarity | aberrant mitochondrion morphology | increased cell size | increased basal disc size | decreased growth rate | aberrant stalk formation | aberrant nucleus morphology | aberrant endosome morphology | delayed development | aberrant pseudopod formation | increased phagocytosis | aberrant fruiting body morphology
DBS0349839dymA-/ [dymA]: dymAdymAwild type
HJW117ecmA-ecmAthin fingers | weak slime trail | long fingers
HJW01ecmB-ecmBwild type
HJW03ecmB-ecmBwild type
DBS0235944ecmF-ecmFwild type
DBS0235946egeB-egeBdevelopment arrests at mound stage
DBS0302590elmoA-elmoAdecreased culmination | increased pseudopod formation | increased localization of protein to the pseudopodium | increased F-actin polymerization | decreased cell motility | delayed development | abolished cell polarity | increased phagocytosis
DBS0302591elmoA-/ [act15]: elmoA: GFPelmoAwild type
DBS0302448epnA-epnAaberrant spore morphology | decreased spore viability | aberrant cytokinesis | abolished protein phosphorylation | aberrant protein localization
DBS0302457epnA-/ [act15]: GFP: epnA(253-677)epnAabolished localization of protein to the plasma membrane | aberrant spore morphology | abolished localization of protein to coated pits
DBS0302456epnA-/ [act15]: epnA(1-133): GFPepnAaberrant localization of a protein to coated pits
DBS0302474epnA-/ [act15]: epnA(R65A/ K78A): GFPepnAabolished localization of protein to the plasma membrane | aberrant spore morphology | abolished phosphatidylinositol-4,5-bisphosphate binding | abolished localization of protein to coated pits
DBS0302475epnA-/ [act15]: epnA(T107A): GFPepnAaberrant spore morphology
DBS0302454epnA-/ [act15]: epnA: GFPepnAwild type
DBS0235947eppA-eppAdecreased growth rate | delayed development | decreased chemotaxis to folate | decreased chemotaxis to cAMP | decreased intracellular cAMP level
DBS0235948eppA-/ [act6]: myc: eppAeppAwild type
HS174erkB-erkBdecreased cell motility | abolished aggregation | decreased chemotaxis to cAMP | decreased cAMP-induced cAMP pulse | decreased sporulation
AK240erkB-erkBabolished aggregation | decreased cAMP-induced cAMP pulse | decreased sporulation
DBS0304864expl7-expl7wild type
DBS0235951fadA-fadAincreased resistance to heat shock
DBS0235952fadB-fadBwild type
DBS0236034fam45-fam45wild type
DBS0236040fam91-fam91wild type
DBS0235953fbxA-fbxAdecreased sporulation
DBS0235954fbxA-/ [ecmA]: GFP(S65T)fbxAincreased prespore cell differentiation
DBS0235956fbxA1-fbxAdevelopment arrests at slug stage | increased slug migration | aberrant fruiting body morphology | delayed culmination
DBS0235957fbxA2-fbxAdevelopment arrests at slug stage | increased slug migration | aberrant fruiting body morphology | delayed culmination
DBS0235958fbxA3-fbxAdevelopment arrests at slug stage | increased slug migration | aberrant fruiting body morphology | delayed culmination
DG1148fcpA-fcpAaberrant fruiting body morphology
DBS0235960fcsA-fcsAdecreased fatty acid level
DBS0235961fimA-fimAdecreased cell size
HM1253fncD2-fncD2increased sensitivity to cisplatin
HM1416fncE-fncEincreased sensitivity to cisplatin
HM1356fncI-fncIincreased sensitivity to cisplatin
HM1302fncL-fncLincreased sensitivity to cisplatin
HM1407fncM-fncMincreased sensitivity to cisplatin
DBS0235966forA-forAwild type
DBS0235968forB-forBwild type
DBS0235969forC-forCaberrant culmination | development arrests at tipped mound stage | aberrant fruiting body morphology
DBS0304905forC-/ [act15]: GFP-forCforCwild type
DBS0235970forH-forHdecreased cell-substrate adhesion | decreased chemotaxis rate | increased cell motility | aberrant pseudopod formation | aberrant cell morphology | decreased filopodium formation
DBS0235971forH-/ [act15]: GFP: forHforHincreased filopodium formation | decreased cell motility | increased cell-substrate adhesion
DBS0302506frmA-frmAdelayed aggregation | decreased cell motility | increased cell-substrate adhesion | decreased aggregate size | aberrant cell morphology
DBS0304440frmA-/ [unk]: GFPfrmAdecreased gene expression | increased cell-cell adhesion | delayed development | aberrant development | abolished phototaxis
DBS0302507frmA-/ [unk]: frmA-HAfrmAwild type
DBS0235976fszA- fszAdecreased number of mitochondria | increased number of tubular mitochondria
DBS0235980fszB- fszBdecreased number of mitochondria | increased number of tubular mitochondria | decreased growth rate
DG1066fut1-fut1aberrant fruiting body morphology
DBS0305025gabT-gabTprecocious development | decreased sporulation
DBS0305026gabT-[pkaC]: pkaCgabT | pkaCaberrant protein secretion
DG1094gacT-gacTaberrant fruiting body morphology
DBS0235989gadA-gadAabolished SDF production | decreased sporulation
TL198gbfA-gbfAabolished gene expression | development arrests at mound stage
DBS0305094gbfA-gbfAabolished autophagic cell death | abolished autophagic vacuole formation
DBS0235993gbpB-pdeEaberrant chemotaxis to cAMP
DBS0235994gbpC-gbpCdecreased myosin light chain kinase activation | decreased fruiting body size
DBS0235995gbpC-gbpCdecreased cell polarity | aberrant myosin II organization | decreased chemotaxis rate | aberrant cell morphology | decreased fruiting body size
DBS0302680gbpC-gbpCdecreased aggregate size | abolished aggregation
DBS0304912gbpC-/ [act15]: gbpCgbpCwild type
DBS0304917gbpC-/ [act15]: gbpC(1-1698: 2005-2631)gbpCdecreased chemotaxis to cAMP
DBS0304918gbpC-/ [act15]: gbpC(311-2631)gbpCdecreased chemotaxis to cAMP
DBS0304916gbpC-/ [act15]: gbpC(F1892A)gbpCdecreased chemotaxis to cAMP
DBS0304915gbpC-/ [act15]: gbpC(F2082A/ E2084A/ F2564A/ E2566A)gbpCdecreased chemotaxis to cAMP
DBS0304913gbpC-/ [act15]: gbpC(K342N)gbpCdecreased chemotaxis to cAMP
DBS0304914gbpC-/ [act15]: gbpC(K905W)gbpCdecreased chemotaxis to cAMP
DBS0235997gbpD-gbpDdecreased lateral pseudopod formation | decreased cell-substrate adhesion | increased cell polarity | increased chemotaxis rate
DBS0235998gbpD-/ [act15]: gbpDgbpDaberrant F-actin organization | increased cell-substrate adhesion | increased lateral pseudopod formation | decreased chemotaxis rate | abolished aggregation
DG1120gbqA-gbqAaberrant fruiting body morphology
DBS0236002gcsA-gcsAabolished gene expression | development arrests at mound stage | inviable | cell cycle arrest | spores inviable
DBS0236003gcsA-/ [act15]: gcsAgcsAdecreased spore viability | development arrests at mound stage
DBS0236004gdt1-gdt1decreased growth rate in suspension | increased gene expression | precocious aggregation
DBS0237190gdt1-/ [act15]: pkaR(G135E/ G261A)gdt1 | pkaRincreased gene expression | abolished aggregation
DBS0236006gdt2-gdt2increased gene expression | precocious aggregation
RI19gefA-gefAdecreased chemoattractant-mediated F-actin polymerization | decreased cAMP-induced cGMP pulse | decreased chemotaxis rate | abolished activation of adenylate cyclase | abolished aggregation | decreased cAMP-induced cAMP pulse
JB10gefA-gefAabolished aggregation
DBS0236009gefB-gefBaberrant cytoskeleton organisation | abolished pinocytosis | increased basal F-actin level | abolished growth | delayed aggregation | decreased phagocytosis | decreased growth rate | decreased aggregate size | aberrant cell morphology | aberrant fruiting body morphology
DBS0236868gefC-gefCwild type
DBS0236869 (DBS0235543)gefD-gefDwild type
DBS0236870gefE-gefEaberrant thermotaxis | aberrant phototaxis
DBS0236011gefG-gefGwild type
DBS0236012gefK-gefKwild type
DBS0236871gefL-gefLaberrant thermotaxis | aberrant phototaxis
HSB61gefM-gefMincreased cAMP-induced cGMP pulse | aberrant activation of adenylate cyclase activity | development arrests at mound stage | decreased chemotaxis rate | decreased lateral pseudopod suppression | decreased cAMP-induced cAMP pulse
DBS0304968gefQ-gefQabolished Ras guanyl-nucleotide exchange factor activity | increased myosin II assembly | increased lateral pseudopod formation | abolished sorting to prestalk region | decreased fruiting body size | abolished phototaxis | multiple tips in mound
DBS0304985gefQ-/ [act15]: GFP: gefQ(172-654)gefQabolished Ras guanyl-nucleotide exchange factor activity | decreased phototaxis
DBS0304986gefQ-/ [act15]: GFP: gefQ(910-1298)gefQdecreased phototaxis
DBS0236014gefR-gefRwild type
DG1109ggtA-ggtAaberrant fruiting body morphology
DBS0266723glcS-/ DH1glcSaberrant stalk morphogenesis | decreased spore size | decreased intracellular glycogen level | decreased fruiting body size
DBS0266765glcS-/ HMXglcSabolished cellulose biosynthesis | decreased autophagic vacuole formation | aberrant cell morphology
DBS0236078glpD-glpDaberrant glycogen metabolism
DBS0236079gmsA-gmsAdecreased sexual fusion
DBS0236080gmsA-gmsAdecreased sexual fusion
DBS0238384gnt14-gnt14wild type
DBS0238382gnt15-gnt15decreased gene expression | decreased growth rate | increased calcium-independent cell-cell adhesion | abolished aggregation | abolished culmination
DBS0238383gnt15-gnt15decreased gene expression | decreased growth rate | increased calcium-independent cell-cell adhesion | abolished aggregation | abolished culmination
DBS0238390gnt15-/ [act15]: FLAG: gnt15gnt15wild type
DBS0238391gnt15-/ [act15]: FLAG: gnt15gnt15wild type
DBS0236082gol-golincreased resistance to cisplatin
DBS0236087gpaA-gpaAincreased stalk length | decreased stalk width
JH131gpaA-gpaAwild type
DBS0236091gpaA-/ [ecmB]: lacZgpaAdecreased gene expression
DBS0236092gpaA-/ [gpaA]: gpaA(G45V)gpaAdelayed development
DBS0236093gpaA-/ [gpaA]: gpaA(Q206L)gpaAincreased basal disc size
DBS0236575gpaB-gpaBdecreased cAMP-induced cGMP pulse | decreased cAMP-induced cAMP pulse
JH104gpaB-gpaBdecreased gene expression | abolished activation of adenylate cyclase | abolished aggregation
DBS0236096gpaB-/ [act15]: gpaBgpaBabolished aggregation
DBS0266942gpaB-/ [act15]: gpaBgpaBdelayed aggregation
DBS0266939gpaB-/ [act15]: gpaB(1-345): gpaD(337-345)gpaB | gpaDabolished aggregation
DBS0237137gpaB-/ [act15]: gpaB(D154V)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | decreased cAMP-induced cAMP pulse
DBS0237138gpaB-/ [act15]: gpaB(E190G)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased cAMP-induced cAMP pulse
DBS0237139gpaB-/ [act15]: gpaB(I104S)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | decreased cAMP-induced cAMP pulse
DBS0237140gpaB-/ [act15]: gpaB(L110S)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | decreased cAMP-induced cAMP pulse
DBS0237141gpaB-/ [act15]: gpaB(L76P)gpaBabolished aggregation
DBS0237142gpaB-/ [act15]: gpaB(N74D)gpaBdecreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0237143gpaB-/ [act15]: gpaB(R64G)gpaBdecreased chemotaxis rate | abolished aggregation
DBS0237144gpaB-/ [act15]: gpaB(S155P)gpaBdecreased chemotaxis rate | abolished aggregation
DBS0236097gpaB-/ [gpaA]: gpaBgpaBabolished aggregation
DBS0236099gpaB-/ [gpaB]: gpaBgpaBwild type
DBS0236098gpaB-/ [gpaB]: gpaB(Q208L)gpaBaberrant protein localization
DBS0235986gpaC-gpaCincreased protein kinase A activity | aberrant activation of adenylate cyclase activity | decreased gene expression | abolished aggregation
JH417gpaD-gpaDdecreased gene expression | abolished SDF production | decreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology | decreased sporulation
DBS0266944gpaD-/ [act15]: gpaBgpaB | gpaDdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0266946gpaD-/ [act15]: gpaB(1-345): gpaD(337-345)gpaB | gpaDdecreased accumulation of cGMP | aberrant fruiting body morphology
DBS0266943gpaD-/ [act15]: gpaDgpaDwild type
DBS0266945gpaD-/ [act15]: gpaEgpaD | gpaEdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0266947gpaD-/ [act15]: gpaE(1-339): gpaD(337-345)gpaD | gpaEdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
JH257gpaE-gpaEdelayed tip formation | delayed gene expression
DBS0266941gpaE-/ [act15]: gpaEgpaEprecocious tip formation
DBS0266948gpaE-/ [act15]: gpaE(1-339): gpaD(337-345)gpaD | gpaEprecocious tip formation
LW1gpaG-gpaGwild type | aberrant gamma-aminobutyric acid signaling pathway | abolished SDF production
DBS0236107gpaH-gpaHwild type
DBS0236108gpaH-gpaHwild type
DBS0236109gpaI-gpaIprecocious aggregation | decreased aggregate size | increased number of aggregates | decreased fruiting body size
LW5gpbA-gpbAabolished aggregation
LW6gpbA-gpbAdecreased CRAC localization to the plasma membrane | decreased positive regulation of Ras GTPase activity | decreased cAMP-induced cGMP pulse | decreased chemotaxis to folate | decreased chemotaxis to cAMP | decreased cAMP-induced cAMP pulse | aberrant protein localization
DBS0304814grlA-grlAdecreased gene expression | abolished SDF production | decreased number of spores | delayed gene expression | delayed culmination
DBS0304815grlA-/ [act15]: grlA: GFPgrlAaberrant tip formation
DBS0236112grlE-grlEabolished SDF production | aberrant gamma-aminobutyric acid signaling pathway | decreased sporulation
DBS0236113grlE-grlEdelayed aggregation | aberrant gene expression | decreased chemotaxis to cAMP
DBS0238865grlJ-grlJaberrant spore morphology | decreased spore viability | increased slug size | precocious development | decreased fruiting body size | precocious gene expression
DBS0238866grlJ-/ [act15]: grlJ: GFPgrlJwild type
DBS0238686grpA-grpAdecreased spore germination | abolished protein secretion
DBS0238687grpA-/ [act15]: grpA-FLAGgrpAwild type
ARK200gskA-gskAincreased gene expression | decreased gene expression | decreased chemotaxis to cAMP | abolished streaming | decreased sporulation
DBS0236114gskA-gskAdecreased slug migration | aberrant sorus morphology | decreased stalk length
HM338gskA-gskAprecocious aggregation | decreased prespore cell differentiation | aberrant fruiting body morphology | increased prestalk cell differentiation | decreased sporulation
DBS0349800gskA-/ [ecmA]: LacZgskAaberrant gene expression
DBS0349801gskA-/ [ecmB]: LacZgskAaberrant gene expression
DBS0266891gtaC-gtaCabolished stalk cell differentiation in vitro | aberrant streaming | decreased aggregate size | aberrant prestalk B cell differentiation
DBS0236120gxcA-gxcAdecreased chemoattractant-mediated F-actin polymerization | delayed development | decreased positive regulation of Rac GTPase activity
DBS0236121gxcB-gxcBdecreased exocytosis | aberrant cytoskeleton organisation | delayed development
DBS0238825gxcDD-gxcDDaberrant streaming | delayed development
DBS0236129hbx2-hbx2wild type
DBS0236130hbx2-hbx2wild type
DBS0236153hcpA-hcpAdecreased growth rate in suspension at low temperature
DBS0236157hcpB-hcpBwild type
DBS0305109hdaB-hdaBdecreased sporulation | decreased histone deacetylase activity
HM1012helC-helCdecreased gene expression | delayed development | aberrant fruiting body morphology
HM444helC-helCdecreased gene expression | delayed development | aberrant fruiting body morphology
DG1059helE-helEincreased slug migration
DBS0236163helF-helFincreased stalk cell differentiation | increased slug size | delayed development | increased gene silencing by RNA interference
DBS0238583hipA-hipAaberrant spore morphology | decreased spore viability | aberrant spore coat morphology
DBS0252818hssA-hssAwild type
DBS0349776htt-httdecreased growth rate in suspension | aberrant cell separation during cytokinesis | decreased chemotaxis rate | delayed development | delayed gene expression | decreased myosin II assembly
DBS0349788htt-httaberrant aggregation | development arrests at loose aggregate stage | aberrant spore morphology | decreased spore viability | aberrant response to hypo-osmotic stress | aberrant F-actin organization | decreased number of spores | aberrant response to starvation | abolished streaming | aberrant development | multiple tips in mound | aberrant prespore cell differentiation | abolished calcium-independent cell-cell adhesion
DBS0349794ibrA-ibrAaberrant stalk formation
DBS0252699icmA-icmA-1 | icmA-2abolished sporulation | aberrant signal transduction during aggregation | abolished growth | development arrests at mound stage | abolished cell polarity | abolished streaming | aberrant cAMP wave formation | delayed gene expression | aberrant fruiting body morphology | aberrant protein localization
DBS0252702icmA-/ [act15]: TAP: YFP: rasGicmA-1 | icmA-2 | rasGabolished C-terminal protein amino acid methylation
DBS0252701icmA-/ [act15]: hICMTicmA-1 | icmA-2wild type
DBS0252700icmA-/ [act15]: icmAicmA-1 | icmA-2wild type
DBS0236421icpA-icpAaberrant mitosis | aberrant cytokinesis | aberrant protein localization
DBS0238521icpA-/ [act15]: GFP: icpA(1-1013)icpAaberrant protein localization
BS153ifkA-ifkAincreased aggregate size | precocious aggregation | decreased extracellular counting factor component(s) level | precocious gene expression
BS160ifkB-ifkBincreased gene expression
DBS0236425ino1-ino1decreased intracellular myo-inositol level | abolished growth | decreased phagocytosis | increased intracellular 2,3-bisphosphoglycerate level | multiple tips in mound
DBS0266326iplA-iplAabolished cellulose biosynthesis | abolished autophagic vacuole formation | abolished autophagic cell death
HM1038iplA-iplAabolished cAMP-induced Ca2+ influx | precocious aggregation | delayed aggregation | increased chemotaxis to arachidonic acid
DBS0252878iptA-iptAdecreased spore viability
DBS0236031kctd9-kctd9wild type
DBS0236489kif12-kif12aberrant myosin II organization | aberrant cytokinesis | aberrant protein localization
DBS0236490kif12-/ [act15]: FLAG: kif12kif12wild type
DBS0302534kif13-kif13decreased spindle stabilization | precocious spindle elongation
DBS0236494kif7-kif7aberrant cell motility
DBS0236491kil1-kil1abolished resistance to pathogenic bacteria
DBS0236492krsA-krsAdecreased chemotaxis to cAMP
DBS0238720krsA-krsAaberrant response to hyperosmotic stress | precocious culmination | abolished activation of adenylate cyclase | decreased aggregate size | decreased intracellular cAMP level | precocious gene expression | abolished streaming | decreased cell size
DBS0236493krsA-/ [act15]: GFP: krsAkrsAwild type
DBS0238721krsA-/ [act15]: GFP: krsAkrsAwild type
DBS0238722krsA-/ [act15]: GFP: krsA(K49R)krsAaberrant streaming
DBS0238723krsA-/ [act15]: GFP: krsA(T173A)krsAabolished streaming
DBS0238725krsA-/ [act15]: GFP: krsA(deltaC)krsAaberrant streaming
DBS0238724krsA-/ [act15]: GFP: krsA(deltaKinase)krsAabolished streaming
DBS0238726krsA-/ [act15]: GFP: krsA(deltaNS)krsAabolished streaming
DBS0236495ku80-ku80increased sensitivity to DNA-damaging agents
AK127lagC-tgrC1development arrests at loose aggregate stage | aberrant aggregation | increased aggregate size
DBS0236498lagD-tgrD1aberrant aggregation | aberrant cAMP signaling during aggregation | abolished streaming
DBS0236499limB-limBdecreased cell polarity | decreased cell-substrate adhesion | decreased gene expression | development arrests at mound stage | aberrant F-actin organization | aberrant cell-cell adhesion | decreased chemotaxis rate | abolished sorting to prestalk region | delayed gene expression
DBS0236502limB-/ [act15]: paxB: GFPlimB | paxBdevelopment arrests at mound stage
DBS0236500limB-/ [cotC]: limBlimBdevelopment arrests at mound stage
DBS0236501limB-/ [ecmAO]: limBlimBwild type
DBS0236503limE-limEaberrant cytokinesis
DBS0236506limF-limFdecreased phagocytosis
DBS0236511lipA-lipAwild type
DBS0236512lipA-lipAwild type
DG1006lipA-lipAabolished culmination
DG1056lipB-captCaberrant fruiting body morphology
DBS0236516lrrA-lrrAdecreased cell polarity | increased aggregate size | decreased cell-substrate adhesion | increased basal F-actin level | decreased spore viability | abolished chemotaxis | decreased gene expression | development arrests at mound stage | abolished aggregation | aberrant cell morphology | delayed gene expression
DBS0236517lst8-lst8decreased F-actin polymerization | aberrant activation of adenylate cyclase activity | decreased chemotaxis rate | abolished aggregation | decreased myosin II assembly
AD60lvsA-lvsAaberrant contractile vacuole organization and biogenesis | abolished cytokinesis | decreased pinocytosis | aberrant response to hypo-osmotic stress | decreased phagocytosis | increased cell-substrate adhesion
AD63lvsA-lvsAabolished cytokinesis | abolished cAMP-induced Ca2+ influx
DBS0236521lvsB-lvsBincreased secretion of lysosomal enzyme | increased lysosome size | increased exocytosis | aberrant post-lysosome organization and biogenesis | increased pinocytosis
DBS0236522lvsC-lvsCwild type
DBS0236523lvsD-lvsDwild type
DBS0236524lvsE-lvsEwild type
DBS0236525lvsF-lvsFwild type
DBS0236536malA-malAwild type
DBS0236543mekA-mekAdecreased aggregate size | precocious development
DBS0266843mgp1-mgp1aberrant contractile vacuole organization and biogenesis | increased phototaxis | increased filopodium formation | decreased cell motility | decreased fruiting body size | abolished streaming | decreased stalk width | decreased stalk length
DBS0266846mgp1-/ mgp2-mgp1 | mgp2aberrant contractile vacuole organization and biogenesis | increased filopodium formation | aberrant culmination | decreased cell motility | decreased phototaxis | decreased stalk length
DBS0266844mgp2-mgp2increased aggregate size | increased slug size
HS1mhcA-mhcAaberrant protein localization
HS2207mhcA-mhcAabolished cytokinesis | development arrests at mound stage
HS2206mhcA-mhcAabolished bleb formation
HK323mhcA-mhcAdecreased cell motility
DBS0266674mhcA-/ [act15]: GFP: abpC(9-148)abpC | mhcAdecreased uropod retraction | decreased pseudopod retraction
DBS0237564mhcA-/ [act15]: GFP: ctxA/ [RNAi]enlActxA | enlA | mhcAaberrant cytokinesis, contractile ring contraction
DBS0266675mhcA-/ [act15]: GFP: mhcA(E476K)mhcAdecreased pseudopod retraction
DBS0236548mhcA-/ [act15]: GFP: pats1(2087-2351)mhcA | pats1aberrant cytokinesis
DBS0236549mhcA-/ [act15]: limE(1-145): GFPlimE | mhcAincreased F-actin polymerization
DBS0238158mhcA-/ [act15]: mhcA(81-2116)mhcAdecreased growth rate | development arrests at tipped mound stage
CW0401mhcA-/ [act15]: mhcA(T1823A/ T1833A/ T2029A)mhcAdecreased growth rate in suspension | increased myosin II assembly
DBS0236550mhcA-/ [act15]: mhcA(T1823A/ T1833A/ T2029A)mhcAdecreased filopodium formation
DBS0236551mhcA-/ [act15]: mhcA(T1823D/ T1833D/ T2029D)mhcAincreased filopodium formation
DBS0238399mhcA-/ [act15]: rapA(G12V)mhcA | rapAincreased basal F-actin level | aberrant myosin II organization | increased cell polarity
DBS0236552mhcA-/ [mhcA]: mhcA(1-1224)mhcAaberrant cytokinesis | development arrests at mound stage
DBS0238157mhcA-/ [mhcA]: mhcA(1-1224)/ [act15]: mhcA(R689H)mhcAdecreased actin filament sliding
DBS0236547mhcA-/ [unk]: GFP: icpAicpA | mhcAaberrant protein localization
CW0371mhkA-mhkAincreased myosin II assembly
DBS0236557mhkA-/ [act15]: mhkAmhkAdecreased growth rate in suspension | development arrests at mound stage | aberrant cytokinesis | decreased myosin II assembly
CW0166mhkB-mhkBincreased myosin II assembly
CW0403mhkC-mhkCincreased myosin II assembly | aberrant cytokinesis
DG1069mhkC-mhkCaberrant fruiting body morphology
CW0435mhkD-mhkDincreased myosin II assembly
DBS0236559midA-midAdecreased growth rate in suspension | aberrant spore morphology | decreased thermotaxis | increased intracellular glutamate level | decreased intracellular glycogen level | increased extracellular ammonia level | increased slug migration | decreased growth rate on bacterial plates | decreased cell size | decreased phototaxis
DG1020migA-migAabolished slug migration | decreased fruiting body size | aberrant fruiting body morphology
DBS0266620mipp1-mipp1aberrant inositol phosphate metabolic process | increased response to lithium
DBS0236560mkcA-mkcAdecreased gene expression
DG1101mkcB-mkcBdecreased fruiting body size
DBS0236564mkkA-mkkAprecocious culmination | decreased sorus size | increased stalk length
DG1121mkpA-mkpAabolished aggregation
DBS0236566mlcE-mlcEdecreased growth rate in suspension | aberrant cytokinesis | delayed aggregation | decreased cell motility | mislocalized gene expression | aberrant development
DBS0238058mlcE-/ [act15]: myc: mlcEmlcEwild type
DBS0236567mlcR-mlcRaberrant myosin II organization | aberrant cytokinesis | development arrests at mound stage
HS183mlkA-mlkAaberrant cytokinesis
DG1033modA-modAaberrant fruiting body morphology
DBS0266903mpl1-mpl1decreased cell motility | decreased chemotaxis to cAMP | abolished streaming | abolished aggregation
DBS0266904mpl1-/ [act15]: flag: mpl1mpl1wild type
DBS0236569mrps4-mrps4delayed aggregation | aberrant fruiting body morphology
HM1463mus81-mus81wild type
DBS0236570mybB-mybBdecreased cAMP-induced cGMP pulse | decreased gene expression | decreased activation of adenylate cyclase | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0236571mybB-mybBabolished aggregation
HM388mybC-mybCdecreased SDF production | decreased gene expression | abolished culmination
DBS0236572mybE-mybEincreased slug size | abolished outer basal disc formation
DBS0237709mybE-/ [mrrA]: lacZmrrA | mybEaberrant prestalk cell differentiation
DBS0236573mybE-/ mybE: GFPmybEwild type | aberrant prestalk cell differentiation
HDT1myoA-myoAdelayed aggregation | decreased cell motility | decreased chemotaxis rate | decreased lateral pseudopod suppression
HDT2myoA-myoAincreased secretion of lysosomal enzyme
DBS0236579myoB-myoBincreased secretion of lysosomal enzyme
DBS0236580myoB-myoBdecreased phagocytosis | delayed aggregation | decreased cell motility | decreased lateral pseudopod suppression
DBS0236583myoB-/ [AS]myoDmyoB | myoDdecreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased cell motility | decreased aggregate size
DBS0236584myoB-/ [AS]myoD/ [KD]myoCmyoB | myoC | myoDsmall pinosomes | decreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased cell motility | increased number of pinosomes | decreased aggregate size
DBS0236585myoC-myoCdecreased phagocytosis
DBS0236587myoD-myoDwild type
HDT8myoF-myoFwild type
DBS0236589myoI-myoIdecreased spore germination
DBS0236592myoI-myoIdecreased cell-substrate adhesion | aberrant cytokinesis | decreased phagocytosis | aberrant cell morphology
HDT15myoI-myoIdecreased phagocytosis
HDT17myoI-myoIdecreased cell-cell adhesion | decreased protein level | decreased cell-substrate adhesion | decreased phagocytosis | decreased filopodium formation
DBS0266889myoI-/ [act15]: GFP: myoImyoIwild type
DBS0266890myoI-/ [act15]: GFP: myoI(809-1154)myoIdecreased phagocytosis
DBS0237617myoI-/ [act15]: gbpDgbpD | myoIincreased pseudopod formation | increased cell-substrate adhesion | aberrant cell morphology
HTD7myoJ-myoJwild type
DBS0349844myoK-myoKaberrant cortical actin cytoskeleton stabilization | delayed aggregation | decreased phagocytosis | aberrant engulfment during phagocytosis | decreased chemotaxis rate | aberrant cell morphology
DBS0349846myoK-/ [act15]: YFP: myoK(1-121: 262-858)myoKdecreased phagocytosis
DBS0349850myoK-/ [act15]: myoKmyoKincreased phagocytosis
DBS0349854myoK-/ [act15]: pakB(1-337: 563-852)myoK | pakBwild type
DBS0236595myoM-myoMwild type
SB12napA-napAdecreased cell-cell adhesion | decreased cell polarity | decreased cell-substrate adhesion | decreased cell motility | decreased basal F-actin level | decreased cell size | decreased phototaxis
HC476ncsA-ncsAincreased intracellular cAMP level | precocious gene expression | precocious development
HC477ncsA-ncsAincreased intracellular cAMP level | precocious gene expression | precocious development
DBS0304633nfaA-nfaAaberrant localization of protein to the plasma membrane | increased pseudopod formation | increased chemoattractant-mediated F-actin polymerization | increased basal F-actin level | delayed aggregation | decreased cell motility | aberrant cAMP signaling during aggregation | aberrant regulation of Ras GTPase activity | aberrant regulation of protein kinase activity | decreased chemotaxis to cAMP
DBS0236604nhe1-nhe1decreased intracellular pH level | decreased cell polarity | aberrant F-actin organization | decreased chemotaxis rate
DBS0349841nhe1-/ [act15]: mhcA: GFPmhcA | nhe1aberrant protein localization
DBS0236605nhe1-/ [act15]: nhe1: HAnhe1wild type
DBS0236606nosA null (15-S-12)nosAdevelopment arrests at mound stage
DBS0236607nosA null (2E4)nosAdevelopment arrests at mound stage
DBS0235950nosA-nosAdevelopment arrests at mound stage
DBS0236608noxA-noxAabolished sporulation | aberrant development
DBS0236611noxA-/ [act15]: noxA: myc2noxAaberrant fruiting body morphology
DBS0236612noxB-noxBabolished sporulation | decreased superoxide production | aberrant development
DBS0236613noxC-noxCabolished sporulation | aberrant development
DBS0238849npcA-npcAwild type
DBS0236695nramp1-nramp1increased infection rate by Mycobacterium avium | increased infection rate by Legionella pneumophila | abolished iron ion transport
DBS0236696nramp1-/ [act15]: nramp1: GFPnramp1decreased infection rate by Legionella pneumophila
DBS0236697nramp1-/ [act15]: nramp1: GFPnramp1decreased infection rate by Legionella pneumophila
DBS0236955nxnA-nxnAdecreased culmination | decreased growth rate | delayed development | decreased chemotaxis to cAMP | decreased lysosomal enzyme activity
DBS0236702nxnA-/ [act15]: GFP: nxnB nxnA | nxnBdevelopment arrests at mound stage
DBS0236704osbA-osbAincreased slug migration | precocious development
DBS0238357p2xA-p2xAaberrant response to hypo-osmotic stress
DBS0304487p2xA-p2xAwild type
DBS0238362p2xA-/ [act15]: p2xA: GFPp2xAwild type
DBS0306166p2xB-p2xBwild type
DBS0306167p2xC-p2xCwild type
DBS0306168p2xD-p2xDwild type
DBS0304486p2xE-p2xEwild type
DBS0236705pakA-pakAaberrant cytokinesis | delayed development
DBS0236706pakA-pakAwild type
DBS0236707pakA-/ [act15]: pakApakAwild type
DBS0236709pakB-pakBdecreased growth rate
DBS0236712pakB-/ [act15]: GFP-pak(1-600)pakBabolished cytokinesis
DBS0236710pakB-/ [act15]: GFP-pakB(1-337: 563-851)pakBabolished cytokinesis | increased pinocytosis | increased phagocytosis
HC392patB-patBabolished growth on bacterial plates | abolished growth in acidic medium
DBS0236726pats1-pats1aberrant cytokinesis
DBS0236727pats1-/ [act15]: GFP: pats1(2087-2351)pats1aberrant cytokinesis
DBS0236728paxB-paxBdecreased cell-substrate adhesion | decreased gene expression | abolished slug migration | development arrests at mound stage | decreased sorting to prestalk region | aberrant fruiting body morphology
DBS0304926paxB-paxBaberrant cell separation during cytokinesis | decreased cell-substrate adhesion | aberrant cytokinesis | decreased cell motility
DBS0304930paxB-/ [act15]: GFP: paxBpaxBwild type
DBS0236730paxB-/ [ecmA]: paxB: GFPpaxBdecreased sorting to prestalk region
DBS0236732paxB-/ [pspA]: paxB: GFPpaxBdecreased sorting to prestalk region
DBS0236733pcp-pcpwild type
DBS0236734pde4-pde4decreased culmination | delayed slug formation | delayed culmination
DBS0236735pde4-/ [act15]: pde4: GFPpde4wild type
DBS0236736pdeD-pdeDdecreased cAMP-induced Ca2+ influx | delayed cAMP-induced Ca2+ influx | decreased Ca2+-induced Ca2+ influx
UK7pdsA-pdsAdecreased 3',5'-cyclic-AMP phosphodiesterase activity | abolished aggregation
DBS0236741pefA-pefAwild type
DBS0236744pefB-pefBwild type
HW260pgtA-pgtAincreased cell size
DBS0236752phdA-phdAdecreased basal F-actin level | decreased aggregate size | decreased chemotaxis rate | decreased fruiting body size
DBS0236753phdA-/ [act15]: phdAphdAwild type
DBS0236754phdA-/ [act15]: phdA: GFPphdAwild type
DBS0304869phg1A-/ [act15]: phg1a(1-276): phg1b(221-587)phg1a | phg1bdecreased phagocytosis
DBS0304868phg1A-/ [act15]: phg1bphg1a | phg1bincreased secretion of lysosomal enzyme | decreased cell-substrate adhesion | decreased phagocytosis
DBS0304870phg1A-/ [act15]: phg1b(1-220): phg1a(277-642)phg1a | phg1bdecreased phagocytosis
DBS0236755phg1a-phg1aincreased secretion of lysosomal enzyme | decreased cell-substrate adhesion | aberrant cytokinesis | decreased phagocytosis | abolished resistance to pathogenic bacteria | decreased growth rate | development arrests at slug stage
DBS0236757phg1a-/ [act15]: kil1kil1 | phg1awild type
DBS0304866phg1b-phg1bincreased secretion of lysosomal enzyme | decreased phagocytosis | decreased growth rate | abolished culmination
DBS0236758phg2-phg2decreased cell-substrate adhesion | decreased phagocytosis | aberrant cytokinesis | aberrant F-actin organization | decreased cell motility | aberrant response to nutrients | aberrant cell morphology | precocious development | precocious gene expression
DBS0238400phg2-phg2increased filopodium formation | increased basal F-actin level | increased cell-substrate adhesion | decreased chemotaxis to cAMP | aberrant cell morphology | increased phagocytosis
DBS0236760phg2-/ [act15]: GFP: phg2(199-1389)phg2decreased phagocytosis
DBS0237615phg2-/ [act15]: gbpDgbpD | phg2increased pseudopod formation | aberrant cell morphology | abolished chemotaxis to cAMP
HG1648phgA-phgAaberrant contractile vacuole organization and biogenesis | aberrant response to hypo-osmotic stress
DBS0236761phgA-/ [act6]: GFP: lvsAlvsA | phgAaberrant protein localization
DBS0236762phlp1-phlp1decreased growth rate in suspension | decreased cAMP-induced cGMP pulse | aberrant regulation of protein modification | abolished chemotaxis | abolished aggregation | decreased growth rate on bacterial plates | decreased cAMP-induced cAMP pulse | aberrant protein localization
DBS0236763phlp1-/ [OE]: phpl1phlp1wild type
DBS0236764phlp3-phlp3wild type
HW288phyA-phyAabolished sporulation | decreased peptidyl-proline hydroxylation | abolished stalk formation | abolished culmination
DBS0266771phyA-/ [ecmA]: phyA(D132N): mycphyAdecreased peptidyl-proline hydroxylation
DBS0266770phyA-/ [ecmA]: phyA(R276A): mycphyAabolished peptidyl-proline hydroxylation | abolished culmination
DBS0236767pia-piaAaberrant activation of adenylate cyclase activity
DBS0236770piaA-piaAaberrant cytokinesis
DBS0236771piaA-piaAabolished aggregation | decreased myosin II assembly
DBS0304637piaA-piaAdecreased cell polarity | decreased cell motility | decreased chemotaxis rate | aberrant protein tyrosine phosphorylation
DBS0236772pikA-pikAwild type
DBS0236774pikB-pikBwild type
DBS0236776pikC-pikCwild type
DBS0236777pikD1pikDabolished slug migration | delayed aggregation | decreased number of spores | decreased aggregate size | aberrant fruiting body morphology
DBS0236778pikE-pikEwild type
SB16pirA-pirAincreased cell motility | decreased cell size
SB3pirA-pirAincreased pseudopod formation | increased basal F-actin level | increased cell size | decreased cell motility
DBS0235411pkaR-pkaRaberrant response to lithium | aberrant response to valproic acid | decreased fruiting body size
DBS0236786pkgB-pkgBabolished SDF production | development arrests at mound stage
DBS0304638pkgB-pkgBdecreased cell-substrate adhesion | development arrests at mound stage | decreased chemotaxis rate | increased cell motility
DBS0236787pkgB-/ [act15]: pkbApkbA | pkgBwild type
DBS0236789pkgB-/ [act15]: pkgB(K182M)pkgBdevelopment arrests at mound stage
DBS0236790pkgB-/ [gbfA]: pkbApkbA | pkgBwild type
DBS0236791pkgB-/ [gbfA]: pkgBpkgBwild type
DBS0238068plaA-plaAabolished aggregation
DBS0238067plaA-plaAabolished aggregation
DG1067plbG-plbGdecreased stalk width | decreased stalk length
HAD236plc-plcdecreased activation of protein kinase B | decreased CRAC localization to the plasma membrane | aberrant chemotaxis to cAMP | abolished aggregation | decreased localization of protein to the cytoplasm
HD1.19plc-plcaberrant negative chemotaxis
HD10plc-plcwild type
DBS0267125plc-/ [OE]: dagA(PH): GFP/ [OE]: plcdagA | plcincreased CRAC localization to the plasma membrane | decreased chemotaxis to cAMP | aberrant protein localization
DBS0236796pldB-pldBprecocious aggregation
DBS0236797pldB-/ [act15]: pldB: GFPpldBabolished aggregation
DBS0236799plip-plipdelayed aggregation
DBS0236820ponA-ponAprecocious aggregation | decreased lateral pseudopod traction | decreased actin nucleation on plasma membranes | aberrant development
DBS0236821ponA-ponAprecocious aggregation | decreased lateral pseudopod traction | decreased actin nucleation on plasma membranes | aberrant development
DG1057potA-potAaberrant fruiting body morphology
DBS0236824ppk1-ppk1decreased phagocytosis | decreased fruiting body size | decreased growth rate on bacterial plates | delayed culmination | decreased sporulation
DBS0236825ppk1-/ [act15]: ppk1ppk1wild type
DBS0238099ppp4C-ppp4cdevelopment arrests at mound stage | delayed development
DBS0238110ppp4C-/ [act15]: smkAppp4c | smkAdevelopment arrests at mound stage | delayed development
DBS0238033proC-proCdecreased cell polarity | increased lateral pseudopod formation | decreased chemotaxis rate
DBS0238034proC-/ [unk]: FLAG: proCproCwild type
DBS0266716pscA-pscAwild type
HOK2psiA-psiAabolished prespore cell division
DBS0236021psiM-psiMwild type
DBS0236022psiM-psiMwild type
DBS0236828pslA-pslAabolished gene expression | abolished sporulation | abolished stalk cell differentiation in vitro | decreased sorus size | increased aggregate size | increased stalk length | mislocalized gene expression
DBS0236829psmC1-psmC1curly fingers | increased resistance to spectinomycin | abolished slug migration | increased cell size
DBS0302352psrA-psrAdecreased culmination | increased protein phosphorylation | delayed development | delayed gene expression | increased protein kinase activation
DBS0302356psrA-/ [act15]: FLAG: gskAgskA | psrAincreased protein kinase activation
DBS0302353psrA-/ [act15]: ecmA: lacZpsrAaberrant gene expression
DBS0302354psrA-/ [act15]: ecmB: lacZpsrAaberrant gene expression
DBS0302357psrA-/ [act15]: gskA(K84M/ K85M)gskA | psrAdecreased culmination | decreased gene expression | delayed development
DBS0302355psrA-/ [act15]: psrApsrAwild type
HM1289pten-ptendecreased cell motility
DBS0236830pten-ptenabolished CRAC localization to the plasma membrane | decreased F-actin polymerization | increased pseudopod formation | decreased growth rate | increased F-actin polymerization | increased lateral pseudopod formation | decreased cell motility | increased CRAC localization to the plasma membrane | decreased chemotaxis to cAMP | abolished aggregation | decreased lateral pseudopod suppression
DBS0236831pten-/ [act15]: GFP: pten-ptenwild type
DBS0236832ptpA1-ptpA1-1decreased prespore cell differentiation | precocious development | increased prestalk O cell differentiation
DBS0236833ptpB-ptpBincreased slug size
DBS0236835pufA-pufAprecocious development | aberrant fruiting body morphology
DBS0304391pyk3-pyk3increased gene expression | decreased gene expression | increased prespore cell differentiation | delayed culmination
DBS0304393pyk3-/ [act15]: T7: pyk3pyk3wild type
DBS0236837pyr56-pyr56uracil auxotroph | increased resistance to 5-fluoroorotic acid (5-FOA)
DBS0236838pyr56-pyr56uracil auxotroph | increased resistance to 5-fluoroorotic acid (5-FOA)
DBS0236839qkgA-qkgA-1 | qkgA-2increased aggregate size | delayed aggregation | increased growth rate
DBS0236841racB-racBdecreased chemoattractant-mediated F-actin polymerization | delayed aggregation | decreased basal F-actin level | decreased chemotaxis rate | aberrant fruiting body morphology | decreased myosin II assembly
DBS0236842racC-racCdecreased chemotaxis rate | aberrant cell morphology | aberrant protein localization
DBS0237191racC-/ [act15]: CFP: racCracCincreased chemoattractant-mediated F-actin polymerization
DBS0236843racF2-racF2increased aggregate size | increased cell-cell adhesion | decreased sexual fusion
DBS0236849racG-racGdecreased cell motility
DBS0236850racH-racHdecreased exocytosis | aberrant protein localization
DBS0266936rapgap1-rapgap1decreased positive regulation of Rap GTPase activity | increased basal F-actin level | increased cell-substrate adhesion | decreased cell motility | decreased myosin II assembly
DBS0266937rapgap1-/ [act15]: GFP: rapgap1rapgap1decreased cell-substrate adhesion | increased myosin II assembly | increased basal F-actin level | increased lateral pseudopod formation | increased cell motility | increased positive regulation of Rap GTPase activity
DBS0236852rasB-rasBdecreased growth rate
DBS0236853rasC-/ AX2rasCdecreased activation of protein kinase B | decreased cell motility | abolished aggregation
DBS0236854rasC-/ JH10rasCdecreased activation of protein kinase B | aberrant gene expression | abolished aggregation | abolished chemotaxis to cAMP
DBS0237614rasC-/ [act15]: gbpDgbpD | rasCincreased cell-substrate adhesion | aberrant cell morphology
DBS0236860rasD-rasDaberrant thermotaxis | aberrant phototaxis
DBS0236862rasG-/ AX2rasGdecreased activation of protein kinase B | decreased cAMP-induced cGMP pulse | decreased gene expression | delayed aggregation | delayed gene expression
IR15rasG-/ AX2rasGincreased cell size | decreased growth rate
IR17rasG-/ AX3rasGaberrant cytokinesis | increased cell size | decreased cell motility
DBS0236863rasG-/ JH10rasGdecreased activation of protein kinase B | decreased cAMP-induced cGMP pulse | decreased gene expression | abolished activation of Rap GTPase activity | delayed aggregation | delayed gene expression
DBS0236864rasG-/ [rasG]: rasBrasB | rasGdecreased growth rate in suspension
DBS0236872rasS-rasSdecreased cell polarity
DBS0236873rasS-rasSdecreased growth rate in liquid medium on solid sufaces | aberrant cytoskeleton organisation | decreased rate of endocytosis | increased basal F-actin level | abolished growth in suspension | increased cell motility
DBS0236874rasZ-rasZwild type
DBS0236877rblA-rblAincreased sorting to prestalk region | precocious development | increased prestalk cell differentiation in response to DIF-1 | decreased cell size
DBS0236878rbrA-rbrAincreased gene expression | decreased gene expression | development arrests at slug stage | mislocalized gene expression | decreased sorting to prestalk region | decreased phototaxis | decreased sporulation
DBS0236879rbrA-/ [unk]: rbrArbrAwild type
DBS0236880rckA-rckAdelayed slug formation | increased aggregate size | precocious aggregation | delayed gene expression | increased chemotaxis rate
DBS0236885rckA-/ [act15]: myc: rckArckAdelayed development | decreased chemotaxis rate
DBS0236881rckA-/ [act15]: myc: rckA(C551A)rckAdelayed slug formation | decreased chemotaxis rate
DBS0236882rckA-/ [act15]: myc: rckA(E510G)rckAwild type | decreased chemotaxis rate
DBS0236883rckA-/ [act15]: myc: rckA(E510G/ N511A)rckAdelayed slug formation | decreased chemotaxis rate
DBS0236884rckA-/ [act15]: myc: rckA(K867A)rckAdevelopment arrests at mound stage | decreased chemotaxis rate
FR17rdeA-rdeAprecocious aggregation | decreased aggregate size | precocious development | precocious gene expression | aberrant fruiting body morphology
FR17rdeA-rdeAprecocious aggregation | decreased aggregate size | precocious development | precocious gene expression | aberrant fruiting body morphology
DBS0236886rdeA-/ [act15]: rdeArdeAwild type
DBS0236887recA-recAincreased sensitivity to mitomycin C (MMC) | increased sensitivity to UV light | increased sensitivity to H2O2 (peroxide)
DBS0266664redA-redAdevelopment arrests at mound stage | aberrant mound color
DG1047redA-redAdevelopment arrests at mound stage | aberrant mound color
DBS0236889regA-regAincreased resistance to cisplatin | aberrant chemotaxis to cAMP | aberrant fruiting body morphology
HM332regA-regAdecreased lateral pseudopod suppression
HR45regA-regAaberrant fruiting body morphology
DBS0235706regA-/ [act15]: dhkK(D1125N)dhkK | regAprecocious development | aberrant fruiting body morphology
DBS0235708regA-/ [act15]: dhkK(H825Q)dhkK | regAprecocious development | aberrant fruiting body morphology
HM1351rev3-rev3increased sensitivity to cisplatin
HM1451rev3-/ xpf-rev3 | xpfincreased sensitivity to cisplatin
DBS0236893rgaA-rgaAaberrant cytokinesis | abolished sorting to prestalk region | abolished stalk cell differentiation | abolished culmination | decreased sporulation
DBS0236894rhgA-rhgAwild type
DBS0236902ripA-/ [unk]: ripA(K680E/ R681E)ripAdecreased chemotaxis rate | aberrant development
DBS0236901ripA-/ [unk]ripAripAwild type
DBS0236903rnpA-rnpAincreased gene expression
DBS0238225rpkA-rpkAdevelopment arrests at loose aggregate stage | aberrant response to conditioned medium factor | decreased cell polarity | decreased cell motility | abolished aggregation
DBS0236875rtoA-rtoAdecreased rate of endocytosis | decreased infection rate by Legionella pneumophila | increased prestalk cell differentiation | delayed culmination
DBS0236911rtoA-rtoAdelayed development
DBS0236914rzpA-rzpAaberrant aggregation | decreased slug migration | increased aggregate size | increased gene expression | decreased gene expression | delayed development
DBS0236921sadA-sadAabolished cell-substrate adhesion | decreased phagocytosis | aberrant cytokinesis | aberrant F-actin organization | increased growth rate | aberrant cell morphology
DBS0349790sadA-/ [act15]: sadA(1-923): GFPsadAdecreased cell-substrate adhesion
DBS0349792sadA-/ [act15]: sadA(S924A/ S925A): GFPsadAwild type
DBS0349791sadA-/ [act15]: sadA(S924E/ S925E): GFPsadAdecreased cell-substrate adhesion
DBS0236922sadA-/ [act15]: sadA: GFPsadAwild type
DBS0236924scrA-scrAdecreased basal F-actin level | increased lateral pseudopod formation | multiple tips | decreased fruiting body size | precocious development | decreased cell size
IR46scrA-scrAdecreased cell motility | decreased cell size
IR48scrA-scrAdecreased growth rate | aberrant cytokinesis
DBS0236925scrA-scrAincreased filopodium formation
DBS0237774scrA-/ [unk]: scrA(97-443): GFPscrAaberrant cytoskeleton organisation | increased cell size | aberrant cytokinesis | decreased chemotaxis to cAMP
DBS0237779scrA-/ [unk]: scrA: GFPscrAwild type
DBS0306234secG-secGdecreased cell-substrate adhesion | decreased chemotaxis rate
DBS0236928set1-set1precocious aggregation | abolished histone H3-K4 methylation | precocious gene expression
DG1008sfbA-sfbAdecreased fruiting body size
SA576sgkA-sgkAincreased sensitivity to cisplatin | increased sensitivity to carboplatin | decreased growth rate
HM1091sgkB-sgkBincreased sensitivity to cisplatin | increased sensitivity to carboplatin | decreased growth rate
SA555sglA-sglAaberrant cytoskeleton organisation | increased stalk width | increased resistance to cisplatin | increased aggregate size | decreased gene expression | abolished slug migration | decreased cell motility | decreased chemotaxis rate | decreased fruiting body size | decreased lateral pseudopod suppression | decreased sporulation
SA554sglA-sglAdelayed aggregation | decreased aggregate size
DBS0236934shkA-shkAaberrant aggregation | decreased cell polarity | aberrant F-actin organization | decreased phagocytosis | aberrant cytokinesis | decreased chemotaxis rate | decreased fruiting body size
DBS0236935sibA-sibAdecreased cell-substrate adhesion | decreased phagocytosis
DBS0302653sibC-sibCdecreased phagocytosis
DBS0236936sigB-sigBwild type
DBS0236937sigD-sigDwild type
DBS0236938smkA-smkAaberrant cytokinesis | delayed development | decreased chemotaxis rate | decreased myosin II assembly
HDB7YAsmlA-smlAdecreased secretion of lysosomal enzyme | decreased cell-cell adhesion | decreased cAMP-induced cGMP pulse | decreased GTP-gamma-S-stimulated guanylyl cyclase activity | increased cAMP-induced cAMP pulse | increased resistance to cisplatin | decreased protein level | increased basal F-actin level | increased myosin II assembly | increased protein level | increased extracellular counting factor component(s) level | increased cell motility | decreased fruiting body size | increased intracellular counting factor component(s) level
DBS0304496smlA-/ sslA1(CR11)smlA | sslA1increased fruiting body size
DBS0302523sodC-sodCaberrant cytokinesis
DBS0302524sodC-sodCdecreased positive regulation of Ras GTPase activity | decreased chemoattractant-mediated F-actin polymerization | aberrant aggregation | increased localization of protein to the plasma membrane | aberrant localization of protein to the plasma membrane | increased basal F-actin level | decreased chemotaxis rate | aberrant cell morphology
HL351spiA-spiAdecreased spore viability
DBS0236945splA-splAaberrant spore morphology | increased sorus size | translucent sorus | spores inviable | decreased stalk length
DBS0236947spnA-spnAabolished prespore cell differentiation | development arrests at mound stage | abolished prestalk cell differentiation | aberrant development
DBS0236949sr-srdecreased intracellular pteridine level | decreased spore viability | decreased cytochrome C oxidase activity | decreased growth rate
DBS0236950srfA(1-8): lacZsrfAdecreased slug migration | aberrant fruiting body morphology | delayed culmination
DBS0236951srfA-srfAaberrant spore morphology | aberrant spore coat morphology | decreased spore viability | decreased gene expression
DBS0266691srfB-srfBaberrant cAMP signaling | precocious aggregation | decreased growth rate | increased pinocytosis | aberrant cytokinesis | increased lateral pseudopod formation | abolished streaming | precocious gene expression
DBS0304409srsA-srsAdecreased gene expression | increased gene expression | increased aggregate size | delayed aggregation
DBS0236952stkA-stkAincreased gene expression | decreased gene expression | increased prestalk cell differentiation | aberrant fruiting body morphology | delayed gene expression
HM1157stlA-stlAwild type
HM1154stlB-stlBabolished prestalk B cell differentation | abolished DIF production | decreased prestalk O cell differentiation | abolished lower cup formation | abolished outer basal disc formation | decreased prestalk cell differentiation | aberrant fruiting body morphology
DBS0304547svkA-svkAdelayed cell separation during cytokinesis | aberrant cytokinesis | aberrant fruiting body morphology
DBS0236958t96AregAdecreased spore germination | precocious sporulation
AK1200tagA-tagAabolished SDF production | aberrant fruiting body morphology
AK859tagA-tagAdecreased spore viability | abolished SDF production | multiple tips in mound | increased prestalk A cell differentiation
AK1201tagA-/ [ecmA]: GFPtagAabolished sorting to prestalk region
AK228tagB-tagBdevelopment arrests at mound stage | abolished DIF production | aberrant prestalk A cell differentiation
DBS0236975tagC-tagCdevelopment arrests at mound stage | spores inviable
DBS0236976talA-talAdecreased cell-substrate adhesion | aberrant cytokinesis | decreased phagocytosis | aberrant cell morphology
HG1666talA-talAdecreased cell-cell adhesion | decreased cell-substrate adhesion | aberrant cytokinesis | decreased growth rate | decreased phagocytosis
HG1663talA-talAdecreased cell-substrate adhesion
HG1664talA-talAdecreased growth rate | decreased phagocytosis
HG1665talA-talAdecreased cell-cell adhesion | aberrant cytokinesis
DBS0304585talA-/ [act15]: FLAG: talBtalA | talBdecreased cell-substrate adhesion
DBS0237616talA-/ [act15]: gbpDgbpD | talAincreased pseudopod formation | increased cell-substrate adhesion | aberrant cell morphology
DBS0238395talA-/ [act15]: rapA(G12V)rapA | talAincreased cell-substrate adhesion
DBS0304582talA-/ talB-/ [act15]: FLAG: talBtalA | talBwild type
HKT104talB-talBdecreased slug migration | decreased cell motility | development arrests at tipped mound stage | increased protein level
DBS0302472talB-talBabolished autophagic vacuole formation | abolished autophagic cell death
DBS0304586talB-/ [act15]: talA: GFPtalA | talBaberrant fruiting body morphology
DBS0304820tgrB1-tgrB1development arrests at loose aggregate stage | delayed sporulation | decreased sporulation
DBS0304821tgrC1-tgrC1abolished sporulation | development arrests at loose aggregate stage in the presence of EGTA
AK244tipA-tipAincreased aggregate size | decreased gene expression | development arrests at mound stage | multiple tips
JS56tipB-tipBincreased aggregate size | development arrests at mound stage | multiple tips | multiple tips in mound
JS55tipC-tipCincreased aggregate size | development arrests at mound stage | multiple tips
JS93tipD-tipDincreased aggregate size | development arrests at mound stage | multiple tips
DBS0304519tirA-tirAdecreased growth rate | increased infection rate by Legionella pneumophila
DBS0237017torA-torAdelayed aggregation | decreased growth rate | decreased cell motility | decreased chemotaxis rate
DBS0237018torA-/ [act15]: torA: GFPtorAabolished growth
DBS0237924triA-triAdecreased cell-cell adhesion | aberrant streaming | increased stalk width | aberrant upper cup formation | decreased spore viability | aberrant culminant morphology | decreased spore size | decreased cell fate determination | increased number of aggregates | decreased cell fate commitment
DBS0237996triA-triAaberrant culminant morphology
DBS0237997triA-triAaberrant culminant morphology
DBS0237998triA-/ [act15]: GFPtriAaberrant culminant morphology
DBS0237999triA-/ [ecmAO]: lacZ: [ecmAO]: gustriAincreased prestalk O cell differentiation
DBS0238001triA-/ [psA]: lacZ: [psA]: gustriAincreased prespore cell differentiation
DBS0237022tsg101-tsg101decreased fruiting body size
DBS0302370tsuA-tsuAincreased period of cAMP wave formation | aberrant chemotaxis to folate | aberrant chemotaxis to cAMP | delayed aggregation | decreased aggregate size | abolished cell polarity | decreased fruiting body size
DBS0302383tsuA-/ [unk]: tsuA(1-1774): YFPtsuAabolished localization of protein to the microtubule organizing center | decreased aggregate size | abolished localization of protein to microtubules | decreased fruiting body size
DBS0302385tsuA-/ [unk]: tsuA(1-260): YFPtsuAabolished localization of protein to the microtubule organizing center | abolished localization of protein to microtubules | decreased aggregate size | decreased fruiting body size
DBS0302384tsuA-/ [unk]: tsuA(1774-2247): YFPtsuAabolished localization of protein to the microtubule organizing center | abolished localization of protein to microtubules | decreased aggregate size | decreased fruiting body size
DBS0302382tsuA-/ [unk]: tsuA(K34R): YFPtsuAdecreased aggregate size | decreased fruiting body size
DBS0302381tsuA-/ [unk]: tsuA: YFPtsuAwild type
DBS0237024ubcB-ubcBdevelopment arrests at mound stage | multiple tips
DBS0306165ube2t-ube2tincreased sensitivity to cisplatin
DBS0237025ubpA-ubpAdecreased gene expression | decreased chemotaxis rate | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0237026ubpB-ubpBaberrant sorus morphology | increased gene expression | decreased gene expression | precocious development
DBS0237027ufc1-ufc1wild type
DBS0266763ugpB-/ DH1ugpBdecreased stalk length
DBS0266764ugpB-/ HMXugpBabolished cellulose biosynthesis | decreased autophagic vacuole formation | aberrant cell morphology
DBS0237031vacA-vacAwild type
DBS0237032vacB-vacBdecreased exocytosis
DBS0237034vasP-vasPabolished filopodium formation
DBS0237035vasP-vasPdecreased cell-substrate adhesion | aberrant F-actin organization | decreased chemotaxis rate | decreased lateral pseudopod suppression | decreased cell size | abolished filopodium formation | decreased filopodium formation
DBS0237033vasP-/ [act15]: GFP: vasP(1-264/ 285-380)vasPabolished filopodium formation
DBS0237836vasP-/ [act15]: YFP: wipAvasP | wipAdecreased filopodium formation
DBS0237842vasP-/ [act15]: YFP: wipA/ [act15]: vasP: FLAGvasP | wipAincreased filopodium formation
DBS0237036vasP-/ [act15]: myr: vasPvasPincreased filopodium formation | increased basal F-actin level | aberrant cytokinesis
DBS0237040vasP-/ [act15]: vasPvasPdecreased filopodium formation
DBS0237840vasP-/ [act15]: vasPvasPincreased filopodium formation | increased basal F-actin level
DBS0237037vasP-/ [act15]: vasP(1-110: 231-380)vasPincreased basal F-actin level | aberrant cytokinesis | decreased filopodium formation
DBS0237038vasP-/ [act15]: vasP(1-228)vasPdecreased filopodium formation
DBS0237039vasP-/ [act15]: vasP(111-380)vasPincreased filopodium formation | increased basal F-actin level
DBS0236058vmp1-vmp1aberrant aggregation | decreased exocytosis | decreased pinocytosis | aberrant response to hypo-osmotic stress | decreased gene expression | decreased growth rate
DG1118vps46-vps46increased sorus size
DBS0237046vwkA-vwkAdecreased growth rate in suspension | increased myosin II assembly | aberrant cytokinesis | delayed development | increased protein level | aberrant fruiting body morphology
TL61wacA-wacAwild type
TL99wacA-wacAwild type
DBS0237048warA-warAdevelopment arrests at slug stage | increased basal disc size | decreased prespore cell differentiation | increased prestalk O cell differentiation
DBS0237049warA-warAdevelopment arrests at slug stage | increased basal disc size | decreased prespore cell differentiation | increased prestalk O cell differentiation
DG1053wimA-wimAaberrant fruiting body morphology
DG1064wimA-wimAaberrant fruiting body morphology
HM1458xpc-xpcwild type
HM1403xpf-xpfincreased sensitivity to cisplatin | decreased double-strand break repair via homologous recombination
AK235yakA-yakAabolished aggregation
AK800yakA-yakAabolished aggregation
DBS0237091yakA-/ [crlA]: crlAcrlA | yakAabolished growth
DG1014yelA-yelAdecreased spore viability | precocious sporulation | development arrests at mound stage | aberrant mound color
DBS0349797zak2-zak2decreased gene expression | decreased protein kinase activation | decreased sporulation | aberrant fruiting body morphology
DBS0349798zak2-/ [ecmA]: LacZzak2aberrant gene expression
ARK100-110zakA-zakAdecreased glycogen synthase kinase 3 activity | increased gene expression | decreased gene expression | abolished streaming | decreased chemotaxis to cAMP | delayed culmination | aberrant fruiting body morphology | decreased sporulation
DBS0238142zakA-zakAdevelopment arrests at tipped mound stage
DBS0349803zakA-/ [ecmB]: LacZzakAaberrant gene expression
DG1050zipA-zipAdecreased fruiting body size

Last updated January 28, 2012

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