Dictyostelium Mutants

Phenotypes for Dictyostelium mutants

View other mutant types: All mutant strains - Null - Overexpression - Multiple - Other - Developmental

To view more details, including parent strains and references, click on the corresponding dictyBase ID.

Systematic Name	Strain Descriptor	Associated gene(s)	Phenotypes
DBS0266721	Dd5P4-/ [act15]: Hs-OCRL(D422A)	Dd5P4	decreased phagocytosis
DBS0237041	VatMpr	vatM	decreased phagocytosis \| decreased growth rate \| aberrant intracellular pH level \| increased localization of protein to the cytoplasm
DBS0237236	[AS]: [tet]: trrA	trrA	decreased growth rate \| delayed development \| abolished aggregation
DBS0237228	[AS]GP138A/ [AS]GP138B	cfrA \| cfrB	decreased sexual fusion
DBS0304456	[AS]alrA/ gcsA-	alrA \| gcsA	decreased growth rate in suspension \| cell cycle arrest
DBS0237273	[AS]calA	calA	abolished cytokinesis
DBS0237224	[AS]cmfA	cmfA	abolished aggregation
DBS0237225	[AS]cupB	cupB	abolished aggregation
DBS0237226	[AS]dia1	dia1	decreased gene expression \| precocious aggregation
DBS0238235	[AS]dutA	dutA	wild type
DBS0237229	[AS]gpaA	gpaA	wild type
HPF414	[AS]hspA	hspA	decreased growth rate \| aberrant fruiting body morphology
DBS0238749	[AS]hspA/ snfA	hspA \| snfA	wild type
DBS0252819	[AS]hssA	hssA	wild type
DBS0237230	[AS]ino1	ino1	abolished growth
DBS0236725	[AS]patA	patA	decreased growth rate under Ca2+ stress
DBS0237504	[AS]pikE	pikE	aberrant stalk morphogenesis \| decreased growth rate
DBS0237232	[AS]proA	proA	wild type
DBS0236827	[AS]proA/ proB-	proA \| proB	increased basal F-actin level \| abolished growth \| development arrests at slug stage \| aberrant cytokinesis \| decreased cell motility
DBS0238036	[AS]proA/ proB-/ [act15]: proA	proA \| proB	wild type
DBS0238037	[AS]proA/ proB-/ [act15]: proB	proA \| proB	wild type
DBS0236851	[AS]rapA	rapA	decreased pinocytosis \| aberrant response to hyperosmotic stress \| aberrant osmosensory signaling pathway \| decreased phagocytosis \| inviable \| increased basal phosphorylated actin level
DBS0236904	[AS]rps4	mrps4	delayed aggregation \| aberrant fruiting body morphology
DBS0238748	[AS]snfA	snfA	decreased number of mitochondria \| aberrant mitochondrion organization and biogenesis \| decreased intracellular ATP level \| increased growth rate \| decreased fruiting body size
DBS0304498	[AS]sslA1	sslA1	decreased fruiting body size
DBS0237235	[AS]tcp1	tcp1	decreased growth rate \| development arrests at mound stage \| aberrant fruiting body morphology
DBS0306101	[AS]vatP	vatP	decreased growth rate \| decreased extracellular Ca2+ uptake
DBS0306102	[AS]vatP	vatP	decreased extracellular Ca2+ uptake \| decreased growth rate \| delayed development
DBS0266892	[KD]gtaC	gtaC	abolished stalk cell differentiation
DBS0266893	[KD]gtaC/ [act15]: GFP: gtaC	gtaC	wild type
DBS0302601	[OE]: disgorgin(Q551A)/ disgorgin-	DDB_G0280955	aberrant contractile vacuole organization and biogenesis
DBS0302600	[OE]: disgorgin(R515A)/ disgorgin-	DDB_G0280955	aberrant contractile vacuole organization and biogenesis
DBS0235409	[RNAi]cnbA	cnbA	multiple tips in culminant \| decreased gene expression \| aberrant stalk cell differentiation \| decreased stalk length
DBS0349787	[RNAi]ctnnA	ctnnA	aberrant protein secretion \| aberrant tip formation \| aberrant Golgi localization \| abolished stalk formation \| aberrant centrosome localization \| abolished culmination \| abolished cell polarity \| aberrant protein localization
DBS0237295	[RNAi]fimA	fimA	wild type
DBS0252820	[RNAi]hssA	hssA	wild type
DBS0237310	[RNAi]lipA	lipA	wild type
DBS0237296	[RNAi]pks16	pks16	wild type
DBS0237311	[RNAi]racF2	racF2	abolished growth in suspension
DBS0238734	[RNAi]sdhA	sdhA	abolished aggregation \| decreased phototaxis
DBS0304564	[RNAi]sun1	sun1	aberrant nucleus morphology \| increased cell size
DBS0237818	[RNAi]wipA	wipA	delayed pseudopod formation \| decreased F-actin polymerization at the leading edge \| decreased chemotaxis to cAMP \| decreased filopodium formation
DBS0238108	[act15]: FLAG: ppp4C(H113Q)	ppp4c	development arrests at mound stage \| delayed development
DBS0237132	[act15]: GFP: racH(T18N)	racH	aberrant cytokinesis \| aberrant cell morphology
DBS0238393	[act15]: GFP: rapA(G12V)	rapA	increased cell-substrate adhesion
DBS0238394	[act15]: GFP: rapA(S17N)	rapA	decreased cell-substrate adhesion
DBS0304563	[act15]: GFP: sun1(283-905)	sun1	increased number of centrosomes \| increased cell size \| aberrant nucleus morphology \| aberrant perinuclear space \| aberrant centrosome localization \| aberrant sister chromosome segregation \| decreased localization of a protein to the nuclear envelope
DBS0237227	[act15]: [AS]dia2	dia2	decreased extracellular cAMP level \| aberrant cAMP signaling during aggregation \| abolished aggregation
DBS0238088	[act15]: atg1(K36A)	atg1	abolished macroautophagy \| increased number of autophagosomes \| aberrant cellular response to nitrogen starvation \| abolished aggregation
DBS0252740	[act15]: carA(I104D)	carA-1 \| carA-2	increased cAMP binding \| delayed aggregation \| decreased MAP kinase activation \| aberrant cAMP wave formation
DBS0252744	[act15]: carA(I104E)	carA-1 \| carA-2	increased cAMP binding \| delayed aggregation \| aberrant cAMP wave formation
DBS0252747	[act15]: carA(I104H)	carA-1 \| carA-2	development arrests at loose aggregate stage \| increased cAMP binding \| decreased MAP kinase activation \| abolished cAMP wave formation
DBS0252749	[act15]: carA(I104K)	carA-1 \| carA-2	increased cAMP binding \| decreased MAP kinase activation \| abolished aggregation \| abolished cAMP wave formation
DBS0252746	[act15]: carA(I104N)	carA-1 \| carA-2	development arrests at loose aggregate stage \| increased cAMP binding \| decreased MAP kinase activation \| abolished cAMP wave formation
DBS0252745	[act15]: carA(I104Q)	carA-1 \| carA-2	development arrests at loose aggregate stage \| increased cAMP binding \| decreased MAP kinase activation \| abolished cAMP wave formation
DBS0252750	[act15]: carA(I104R)	carA-1 \| carA-2	development arrests at loose aggregate stage \| increased cAMP binding \| decreased MAP kinase activation \| abolished cAMP wave formation
DBS0252748	[act15]: carA(I104Y)	carA-1 \| carA-2	development arrests at loose aggregate stage \| increased cAMP binding \| decreased MAP kinase activation \| aberrant cAMP wave formation
DBS0237098	[act15]: cdk5(D144N)	cdk5	decreased pinocytosis \| increased aggregate size \| delayed aggregation \| decreased phagocytosis \| decreased growth rate \| decreased extracellular counting factor component(s) level \| increased extracellular counting factor component(s) level \| decreased sporulation \| increased intracellular counting factor component(s) level
DBS0266839	[act15]: myc: ptpΔ(3C649S)	ptpC	aberrant localization of protein to the nucleus \| increased protein tyrosine phosphorylation
DBS0266838	[act15]: myc: ptpC(C649S)	ptpC	aberrant localization of protein to the nucleus \| increased protein tyrosine phosphorylation
DBS0238396	[act15]: myc: rapA(G12V)	rapA	delayed aggregation \| increased cell-substrate adhesion \| decreased cell motility
DBS0238397	[act15]: myc: rapA(S17N)	rapA	decreased cell-substrate adhesion
DBS0237183	[act15]: pakA(K394A)	pakA	development arrests at mound stage \| delayed development
DBS0237184	[act15]: pakA[CA]	pakA	abolished aggregation
DBS0349855	[act15]: pakB(1-337: 563-852)	pakB	decreased phagocytosis
DBS0349793	[act15]: sadA(921-S952)	sadA	decreased cell-substrate adhesion
DBS0306243	[act6]: GFP: sun1	sun1	increased number of centrosomes \| aberrant nucleus morphology \| aberrant sister chromosome segregation \| aberrant centromere complex assembly \| aberrant centrosome organization
DBS0306244	[act6]: GFP: sun1(1-722)	sun1	increased number of centrosomes \| aberrant nucleus morphology \| aberrant sister chromosome segregation \| aberrant centromere complex assembly \| aberrant centrosome organization
DBS0237219	[act6]: ptpC(C649S)	ptpC	increased aggregate size \| decreased growth rate
DBS0237252	[gpaA]: gpaA(G45V)	gpaA	delayed development
DBS0237253	[gpaA]: gpaA(Q206L)	gpaA	increased basal disc size
DBS0238351	[tet]: [RNAi]cinC	cinC	decreased translation \| precocious aggregation \| decreased growth rate
DBS0237318	[tet]: pten	pten	decreased cell motility
DBS0237622	[tet]: rapA(S17N)/ [act15]: gbpD	gbpD \| rapA	increased cell-substrate adhesion \| increased cell polarity \| aberrant cell morphology
DBS0304911	[tre]: paxB	paxB	abolished sporulation \| aberrant endocytosis \| decreased cell-substrate adhesion \| aberrant chemotaxis to folate \| development arrests at mound stage \| decreased cell motility \| increased cell-cell adhesion
DBS0237786	acrA-/ [act15]: acgA(1-401)	acgA \| acrA	decreased gene expression \| decreased prespore cell differentiation \| decreased sporulation
DBS0238093	atg1-/ [act15]: atg1(P138S)	atg1	abolished aggregation
DBS0235570	carB-	carB	development arrests at mound stage
DBS0237568	ctxA-/ [RNAi]enlA	ctxA \| enlA	wild type
DBS0304913	gbpC-/ [act15]: gbpC(K342N)	gbpC	decreased chemotaxis to cAMP
DBS0304914	gbpC-/ [act15]: gbpC(K905W)	gbpC	decreased chemotaxis to cAMP
DBS0237190	gdt1-/ [act15]: pkaR(G135E/ G261A)	gdt1 \| pkaR	increased gene expression \| abolished aggregation
DBS0236092	gpaA-/ [gpaA]: gpaA(G45V)	gpaA	delayed development
DBS0236093	gpaA-/ [gpaA]: gpaA(Q206L)	gpaA	increased basal disc size
DBS0237564	mhcA-/ [act15]: GFP: ctxA/ [RNAi]enlA	ctxA \| enlA \| mhcA	aberrant cytokinesis, contractile ring contraction
DBS0238399	mhcA-/ [act15]: rapA(G12V)	mhcA \| rapA	increased basal F-actin level \| aberrant myosin II organization \| increased cell polarity
DBS0304881	mrps4-	mrps4	delayed aggregation
DBS0304882	mtDNA-	DidioMp05 \| DidioMp21 \| DidioMp26 \| DidioMp27 \| DidioMp30 \| DidioMp35 \| DidioMp36 \| ai2a \| ai2b \| ai3 \| ai4 \| atp1 \| atp6 \| atp9 \| cox1/ 2 \| cox3 \| cytB \| mrpl11 \| mrpl14 \| mrpl16 \| mrpl2 \| mrpl6 \| mrps12 \| mrps13 \| mrps14 \| mrps19 \| mrps2 \| mrps4 \| mrps7 \| mrps8 \| nad1 \| nad11 \| nad2 \| nad3 \| nad4 \| nad4L \| nad5 \| nad6 \| nad7 \| nad9 \| rnlA	abolished growth \| abolished aggregation
DBS0236583	myoB-/ [AS]myoD	myoB \| myoD	decreased pinocytosis \| aberrant aggregation \| decreased growth rate \| decreased phagocytosis \| decreased cell motility \| decreased aggregate size
DBS0236584	myoB-/ [AS]myoD/ [KD]myoC	myoB \| myoC \| myoD	small pinosomes \| decreased pinocytosis \| aberrant aggregation \| decreased growth rate \| decreased phagocytosis \| decreased cell motility \| increased number of pinosomes \| decreased aggregate size
DBS0349854	myoK-/ [act15]: pakB(1-337: 563-852)	myoK \| pakB	wild type
HM1060	nsfA(A1847G, A1939T, T1977C, T2005G, A2025T, A2366T)	nsfA	decreased rate of endocytosis \| decreased phagocytosis \| decreased F-actin polymerization at the leading edge \| abolished cell motility
HM1067	nsfA(A1854T, T1984A, C2131A, A2398T, T2574A)	nsfA	decreased rate of endocytosis \| abolished cell motility \| decreased F-actin polymerization at the leading edge \| decreased cell motility \| increased phagocytosis
DBS0236789	pkgB-/ [act15]: pkgB(K182M)	pkgB	development arrests at mound stage
DBS0302357	psrA-/ [act15]: gskA(K84M/ K85M)	gskA \| psrA	decreased culmination \| decreased gene expression \| delayed development
DBS0236884	rckA-/ [act15]: myc: rckA(K867A)	rckA	development arrests at mound stage \| decreased chemotaxis rate
HM1163	sec1(M213K, E258G, M427V, K527I, T541N, F558S, N581D)	sec1	abolished cell motility
DBS0238395	talA-/ [act15]: rapA(G12V)	rapA \| talA	increased cell-substrate adhesion
DBS0302382	tsuA-/ [unk]: tsuA(K34R): YFP	tsuA	decreased aggregate size \| decreased fruiting body size
DBS0237051	wasA1-	wasA	aberrant F-actin organization \| decreased cell motility \| delayed development
DBS0237052	wasA1-/ [tet]: YFP: wasA2	wasA	decreased F-actin polymerization \| abolished chemotaxis \| aberrant F-actin organization \| abolished aggregation
DBS0237811	wasA1-/ [tet]: YFP: wasA2/ [act15]: wasA(Y33A/ W39A/ F90A/ F91A)	wasA	decreased F-actin polymerization \| decreased F-actin polymerization at the leading edge
DBS0237820	wasA1-/ [tet]: YFP: wasA2/ [act15]: wipA	wasA \| wipA	abolished chemotaxis

Last updated January 28, 2012


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